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CLK1 Knockout Cell Lines

Gene: CLK1

Official Full Name: CDC like kinase 1provided by HGNC

Gene Summary: This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01464 CLK1 Knockout cell line(HEK293) Human CLK1 1:3~1:6 Negative Online Inquiry
KO18665 CLK1 Knockout cell line (HeLa) Human CLK1 1:3~1:6 Negative Online Inquiry
KO18666 CLK1 Knockout cell line (HCT 116) Human CLK1 1:2~1:4 Negative Online Inquiry
KO18667 CLK1 Knockout cell line (A549) Human CLK1 1:3~1:4 Negative Online Inquiry

Background

CLK1 Gene Knockout Cell Lines are engineered cellular models designed to provide researchers with a powerful tool for investigating the role of the CLK1 gene, which encodes a cyclin-dependent kinase involved in cell cycle regulation and developmental processes. These knockout cell lines have been created using advanced gene editing techniques, such as CRISPR-Cas9, to effectively ablate CLK1 expression, allowing for the study of its functions and the resulting phenotypic changes.

The primary function of these cell lines is to serve as a platform for elucidating CLK1's biological mechanisms, particularly its involvement in cellular proliferation, differentiation, and apoptosis. By removing the CLK1 gene, researchers can observe how its absence affects cellular responses to various stimuli, contributing to our understanding of gene regulatory networks and potential oncogenic pathways.

The scientific importance of CLK1 Gene Knockout Cell Lines lies in their applications across a range of research areas, including cancer biology, developmental biology, and pharmacogenomics. The ability to model conditions that mimic CLK1 loss can shed light on disease mechanisms, thereby informing the development of targeted therapies and providing insights into patient-specific responses to treatment.

Compared to traditional cell lines, CLK1 Gene Knockout Cell Lines offer a high level of specificity and reliability for studying CLK1 functions without compensatory mechanisms that often complicate interpretations. Their robust design allows for consistent results across experiments, distinguishing them as a valuable resource for both basic and applied research.

For researchers and clinicians, the CLK1 Gene Knockout Cell Lines represent an opportunity to explore critical biological pathways with minimal interference, facilitating advancements in drug development and therapeutic interventions. By investing in this product, users gain access to a meticulously validated cellular model that supports high-throughput screening and in-depth mechanistic studies.

Our company specializes in the creation and distribution of cutting-edge biological tools that empower scientists to push the boundaries of their research. With expertise in genetic engineering and a commitment to quality, we provide researchers with the resources necessary to achieve groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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