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CLCN4 Knockout Cell Lines

Gene: CLCN4

Official Full Name: chloride voltage-gated channel 4provided by HGNC

Gene Summary: The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38527 CLCN4 Knockout cell line (HeLa) Human CLCN4 1:3~1:6 Negative Online Inquiry
KO38528 CLCN4 Knockout cell line (HCT 116) Human CLCN4 1:2~1:4 Negative Online Inquiry
KO38529 CLCN4 Knockout cell line (HEK293) Human CLCN4 1:3~1:6 Negative Online Inquiry
KO38530 CLCN4 Knockout cell line (A549) Human CLCN4 1:3~1:4 Negative Online Inquiry

Background

CLCN4 Gene Knockout Cell Lines are genetically engineered cells in which the CLCN4 gene has been selectively disrupted, resulting in a model system that allows researchers to study the physiological and pathological roles of this gene in a controlled environment. The CLCN4 gene encodes for a chloride channel that plays a fundamental role in cellular ion homeostasis and membrane potential regulation. By utilizing CRISPR-Cas9 technology or similar genome-editing techniques, these knockout cell lines provide a robust platform to dissect the impact of CLCN4 loss on cellular functions and downstream signaling pathways.

The key function of these knockout cell lines lies in their ability to mimic conditions that are reflective of various disease states associated with CLCN4 dysregulation. This innovative tool enables researchers to investigate ion channel-related disorders, such as those affecting neuronal excitability and muscle contraction. Additionally, CLCN4 knockout cells facilitate studies on drug responses, toxicity, and the functional impact of novel therapeutic agents aimed at restoring normal chloride channel activity.

In research and clinical settings, CLCN4 Gene Knockout Cell Lines are vital for advancing our understanding of genetic contributions to pathophysiology. These cells can be employed in high-throughput screening assays to identify compounds that may have therapeutic potential, paving the way for targeted treatment strategies. Compared to traditional models, these knockout lines provide a higher degree of specificity and relevance to human disease mechanisms, reducing the translational gap in drug development.

What sets our CLCN4 Gene Knockout Cell Lines apart is not only their genetic precision but also our commitment to quality and reproducibility. By providing thoroughly validated cell lines, we ensure that researchers and clinicians can rely on consistent results that drive meaningful discoveries. Our company boasts a rich expertise in molecular biology and a dedicated focus on providing cutting-edge biological products that empower science.

In an era where precise genetic manipulation is paramount, CLCN4 Gene Knockout Cell Lines represent an indispensable asset to any research program aimed at unraveling the complexities of gene function and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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