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CIB2 Knockout Cell Lines

Gene: CIB2

Official Full Name: calcium and integrin binding family member 2provided by HGNC

Gene Summary: The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs), and it is involved in photoreceptor cell maintenance. Mutations in this gene cause deafness, autosomal recessive, 48 (DFNB48), and also Usher syndrome 1J (USH1J). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31763 CIB2 Knockout cell line (HeLa) Human CIB2 1:3~1:6 Negative Online Inquiry
KO31764 CIB2 Knockout cell line (HCT 116) Human CIB2 1:2~1:4 Negative Online Inquiry
KO31765 CIB2 Knockout cell line (HEK293) Human CIB2 1:3~1:6 Negative Online Inquiry
KO31766 CIB2 Knockout cell line (A549) Human CIB2 1:3~1:4 Negative Online Inquiry

Background

CIB2 Gene Knockout Cell Lines are specialized cellular models in which the CIB2 gene has been precisely inactivated or disrupted. This powerful tool allows researchers to study the functional consequences of CIB2 deficiency in vitro, providing insight into its role in various biological processes. The CIB2 gene encodes the calcium and integrin-binding protein 2, which is implicated in cell signaling pathways and has been associated with various physiological functions, including intracellular calcium regulation and cytoskeletal dynamics.

The primary mechanism at work in these knockout cell lines involves the complete removal of the CIB2 gene expression, leading to a lack of CIB2 protein synthesis. This absence enables scientists to observe the downstream effects on cellular behavior, such as changes in migration, adhesion, and proliferation, thereby elucidating the gene’s contribution to essential cellular functions. This is particularly valuable in the study of diseases where CIB2 is suspected to play a key role, such as cardiomyopathies and osteogenesis.

CIB2 Gene Knockout Cell Lines hold significant scientific importance in both research and clinical settings. They provide unparalleled models for studying gene function and can be used for drug screening, identifying potential therapeutic targets, and validating hypotheses regarding the molecular mechanisms underpinning disease. Their utility extends to various fields, including cell biology, pharmacology, and translational research.

What sets our CIB2 Gene Knockout Cell Lines apart from other available models is their robust characterization, ensuring consistency and reproducibility in experimental results. Each line undergoes rigorous validation processes, such as genotyping and protein analysis, affirming the complete knockout of CIB2 expression. Furthermore, we provide comprehensive technical support and detailed protocols to facilitate users in their research endeavors.

For researchers and clinicians seeking to expand their understanding of the biochemical pathways involving CIB2, these cell lines are an invaluable resource. They offer the opportunity to further investigate the links between CIB2 and various health conditions, ultimately aiding in the development of innovative therapeutic strategies.

Our company specializes in producing high-quality biological research tools, supported by a team of experts dedicated to advancing scientific discovery. We are committed to providing reliable, cutting-edge products that empower the research community to make significant breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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