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CHSY3 Knockout Cell Lines

Gene: CHSY3

Official Full Name: chondroitin sulfate synthase 3provided by HGNC

Gene Summary: CSS3 is a glycosyltransferase that has both glucuronyltransferase and N-acetylgalactosaminyltransferase activities (Yada et al., 2003 [PubMed 12907687]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18694 CHSY3 Knockout cell line (HeLa) Human CHSY3 1:3~1:6 Negative Online Inquiry
KO18695 CHSY3 Knockout cell line (HCT 116) Human CHSY3 1:2~1:4 Negative Online Inquiry
KO18696 CHSY3 Knockout cell line (HEK293) Human CHSY3 1:3~1:6 Negative Online Inquiry

Background

CHSY3 Gene Knockout Cell Lines are specialized cellular models in which the CHSY3 gene, responsible for encoding chondroitin sulfate synthase, has been completely disrupted. These cell lines are engineered using advanced CRISPR-Cas9 technology, offering a precise and efficient method to create gene knockout models essential for the functional analysis of gene activity and the study of related biochemical pathways.

The principal function of these knockout cell lines is to facilitate the understanding of the role of CHSY3 in various biological processes, particularly in glycosaminoglycan biosynthesis. By eliminating the CHSY3 gene, researchers can investigate alterations in chondroitin sulfate synthesis, thereby gaining insights into its implications in cell signaling, extracellular matrix organization, and developmental processes. This delineation of function is especially important in the context of diseases such as osteoarthritis and certain cancers, where chondroitin sulfate plays a pivotal role.

The scientific relevance of CHSY3 Gene Knockout Cell Lines extends into various research fields, including developmental biology, regenerative medicine, and cancer research. These cell lines can serve as a robust platform for drug discovery, allowing researchers to screen for compounds that could potentially target CHSY3-related pathways. Furthermore, they provide insights into gene function that aids in elucidating mechanisms of disease, thereby potentially leading to novel therapeutic targets.

What sets our CHSY3 Gene Knockout Cell Lines apart from traditional knockout models is the precision of the gene editing technique used, which results in minimal off-target effects and higher fidelity in gene disruption. Additionally, the availability of these lines in multiple backgrounds (e.g., human, mouse) broadens their utility for diverse experimental setups, addressing a critical need in contemporary biological research.

For researchers and clinicians, the value of CHSY3 Gene Knockout Cell Lines lies in their capacity to expedite the understanding of gene functions and their associated pathways, while providing a reliable foundation for therapeutic advancements. Their unique attributes not only enhance experimental reproducibility but also ensure that researchers are equipped with cutting-edge tools to tackle complex biological questions.

As a company with extensive expertise in gene editing technologies and a commitment to supporting the scientific community, we aim to provide high-quality products that advance research in molecular biology and genetics. Our focus on innovation and scientific rigor reflects in our offerings, ensuring that you have access to the best tools for your research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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