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CELSR1 Knockout Cell Lines

Gene: CELSR1

Official Full Name: cadherin EGF LAG seven-pass G-type receptor 1provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33030 CELSR1 Knockout cell line (HeLa) Human CELSR1 1:3~1:6 Negative Online Inquiry
KO33031 CELSR1 Knockout cell line (HCT 116) Human CELSR1 1:2~1:4 Negative Online Inquiry
KO33032 CELSR1 Knockout cell line (HEK293) Human CELSR1 1:3~1:6 Negative Online Inquiry
KO33033 CELSR1 Knockout cell line (A549) Human CELSR1 1:3~1:4 Negative Online Inquiry

Background

CELSR1 Gene Knockout Cell Lines are specialized biological tools designed for the targeted disruption of the CELSR1 gene, which plays a critical role in cell signaling and developmental processes. These engineered cell lines enable researchers to investigate the functional consequences of CELSR1 loss in various cellular contexts, thereby providing valuable insight into its involvement in developmental abnormalities and diseases, such as certain cancers and neurodevelopmental disorders.

The primary function of CELSR1 Gene Knockout Cell Lines is to facilitate the study of the gene's role in cellular processes such as planar cell polarity, which is essential for tissue organization and function. Utilizing CRISPR-Cas9 technology, these cell lines exhibit precise gene editing, ensuring a reliable and efficient knockout of the CELSR1 gene. This allows researchers to explore downstream signaling pathways and gene interactions, leading to a more comprehensive understanding of the cellular mechanisms at play in both normal physiology and pathological conditions.

In the context of scientific research, CELSR1 Gene Knockout Cell Lines hold significant importance. They serve as essential models for elucidating the gene's role in cell behavior and tissue architecture, which can pave the way for the identification of novel therapeutic targets in cancer treatment and regenerative medicine. In clinical settings, these cell lines are particularly valuable for drug discovery, enabling the testing of therapeutic agents in CELSR1-related disease models and facilitating the development of targeted interventions.

One of the key advantages of our CELSR1 Gene Knockout Cell Lines is their high specificity and reproducibility, which significantly enhance experimental accuracy when compared to traditional methods of gene disruption. Our cell lines are rigorously validated to ensure consistent performance, making them a go-to choice for researchers seeking dependable outcomes. Additionally, the ready-to-use format of our product streamlines research workflows, saving time and resources.

For researchers and clinicians eager to advance their studies in developmental biology and cancer research, CELSR1 Gene Knockout Cell Lines provide essential capabilities that facilitate breakthrough discoveries. Their precise design, coupled with our commitment to quality and innovation in biological solutions, reinforces the reliability and efficacy of our product offerings. Our company’s expertise in genetic engineering and cell line development positions us as a leader in delivering high-impact research tools to the global scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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