Gene: CEL
Official Full Name: carboxyl ester lipaseprovided by HGNC
Gene Summary: The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38597 | CEL Knockout cell line (HCT 116) | Human | CEL | 1:2~1:4 | Negative | Online Inquiry |
KO38598 | CEL Knockout cell line (HEK293) | Human | CEL | 1:3~1:6 | Negative | Online Inquiry |
CEL Gene Knockout Cell Lines are sophisticated biological tools engineered to lack specific target genes, providing researchers with a powerful means to study gene function and its implications in various biological processes. These specialized cell lines are created through advanced genome-editing technologies, such as CRISPR-Cas9, enabling precise deletions that facilitate the examination of gene knockout effects on cellular behavior, signaling pathways, and phenotypic outcomes.
The primary function of these knockout cell lines is to elucidate the roles of specific genes, allowing for the investigation of gene dosage effects, functional pathways, and potential therapeutic targets. By systematically removing or inactivating genes of interest, researchers can explore the consequences of gene disruption in areas such as cancer biology, developmental biology, and neurobiology. This in-depth understanding can lead to the identification of biomarkers and novel drug targets, ultimately contributing to the advancement of precision medicine.
CEL Gene Knockout Cell Lines stand out in the marketplace due to their rigorously validated genetic modifications and reliability in experimental reproducibility. Unlike traditional knockout methods or gene-silencing approaches, these cell lines provide a stable platform for long-term studies, reducing variability linked to transient expression systems. Additionally, their diverse range enables scientists to select the most appropriate model for their specific research needs without the time-consuming development processes typically associated with creating custom models.
For researchers and clinicians, investing in CEL Gene Knockout Cell Lines translates to tapping into cutting-edge technology that enhances experimental accuracy and efficiency. These cell lines not only aid in elucidating complex cellular interactions but also pave the way for innovative therapeutic strategies addressing unmet medical needs.
At CEL Biotech, we pride ourselves on our extensive expertise in cellular biology and genetics. Our commitment to providing high-quality, reliable biological products ensures our customers have access to resources that support groundbreaking research and development.
Please note that all services are for research use only. Not intended for any clinical use.
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