CEACAM1 Knockout Cell Lines

Gene: CEACAM1

Official Full Name: CEA cell adhesion molecule 1provided by HGNC

Gene Summary: This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]

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Products Background

Products

Catalog Number	Product Name	Species	Gene	Passage ratio	Mycoplasma testing	Price
KO01466	CEACAM1 Knockout cell line(HEK293)	Human	CEACAM1	1:3~1:6	Negative	Online Inquiry

Background

CEACAM1 Gene Knockout Cell Lines are specially engineered cellular models designed to facilitate the study of the Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1). This gene plays a crucial role in cell adhesion, immune modulation, and pathogen interactions. By knocking out the CEACAM1 gene, these cell lines allow researchers to investigate its specific functions and regulatory mechanisms in various biological processes, including cancer progression and infectious disease responses.

The primary function of CEACAM1 lies in its involvement in cell signaling pathways that govern immune responses, tumorigenesis, and cellular differentiation. The knockout of this gene elucidates its role in disease states by providing a comparative baseline against wild-type cells. Leveraging techniques such as CRISPR-Cas9 and RNA interference, CEACAM1 Gene Knockout Cell Lines offer a precise and versatile platform for dissecting complex signaling networks and cellular behaviors.

Scientifically, the importance of utilizing these knockout cell lines is substantial, as they serve as valuable tools in both research and clinical settings. They empower scientists to explore therapeutic targets and develop personalized medicine approaches, particularly in oncology and immunology. Moreover, their application extends to drug discovery and testing, enabling researchers to evaluate the efficacy of candidate compounds in CEACAM1-null environments.

The CEACAM1 Gene Knockout Cell Lines stand out due to their robust performance, reproducibility, and ease of use compared to other available models. They are validated and characterized to ensure that they effectively mimic the physiological conditions and mutations being studied, thus providing reliable and relevant data that can be translated into clinical insights.

For researchers and clinicians aiming to uncover the complex interactions in health and disease, these cell lines represent a gateway to groundbreaking discoveries. With years of expertise in biological product development and a commitment to advancing scientific research, our company provides not only high-quality cell lines but also unparalleled support to ensure optimal experimental outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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