Gene: CDS1
Official Full Name: CDP-diacylglycerol synthase 1provided by HGNC
Gene Summary: Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07758 | CDS1 Knockout cell line (HeLa) | Human | CDS1 | 1:3~1:6 | Negative | Online Inquiry |
KO07759 | CDS1 Knockout cell line (HCT 116) | Human | CDS1 | 1:2~1:4 | Negative | Online Inquiry |
KO07760 | CDS1 Knockout cell line (HEK293) | Human | CDS1 | 1:3~1:6 | Negative | Online Inquiry |
KO07761 | CDS1 Knockout cell line (A549) | Human | CDS1 | 1:3~1:4 | Negative | Online Inquiry |
CDS1 Gene Knockout Cell Lines are specially engineered cellular models designed to facilitate the study of the functions and implications of the CDS1 gene, which encodes the enzyme CDP-diacylglycerol synthase. These knockout cell lines provide valuable insights by effectively disabling the CDS1 gene, allowing researchers to observe the resultant phenotypic and molecular changes. By utilizing CRISPR/Cas9 technology or similar gene editing techniques, these cell lines serve as powerful tools for dissecting the role of CDS1 in various biological processes, including lipid metabolism, cellular signaling, and membrane dynamics.
The primary function of CDS1 is to contribute to the synthesis of phosphatidylglycerol and cardiolipin, essential components of mitochondrial membranes. Understanding its knockout effects can elucidate the consequences of disrupted lipid biosynthesis and their associations with metabolic disorders and cardiovascular diseases. In research and clinical settings, the availability of these cell lines allows for the exploration of CDS1’s involvement in drug metabolism, stress responses, and cell survival pathways, enabling targeted therapeutic strategies for disease management.
Compared to traditional models, such as wild-type cell lines or transient transfection methods, the CDS1 Gene Knockout Cell Lines provide a stable, reproducible platform that overcomes limitations associated with gene expression variability. With this reliable genetic alteration, researchers can delve deeper into pathophysiological mechanisms without the confounding effects introduced by residual gene activity.
Researchers and clinicians benefit from the CDS1 Gene Knockout Cell Lines as they represent a cutting-edge approach to investigating dynamic biological systems. By incorporating these advanced models into their studies, users can generate robust data that could advance our understanding of metabolic regulation and related disorders, ultimately informing drug design and clinical interventions.
Backed by years of experience in cellular and molecular biology, our company is dedicated to providing high-quality, innovative products that support research excellence and enhance scientific endeavors. Our commitment to precision and reliability ensures that customers receive the best tools for advancing their work.
Please note that all services are for research use only. Not intended for any clinical use.
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