Gene: CDKN3
Official Full Name: cyclin dependent kinase inhibitor 3provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03248 | CDKN3 Knockout cell line (HeLa) | Human | CDKN3 | 1:3~1:6 | Negative | Online Inquiry |
KO03249 | CDKN3 Knockout cell line (HCT 116) | Human | CDKN3 | 1:2~1:4 | Negative | Online Inquiry |
KO03250 | CDKN3 Knockout cell line (HEK293) | Human | CDKN3 | 1:3~1:6 | Negative | Online Inquiry |
KO03251 | CDKN3 Knockout cell line (A549) | Human | CDKN3 | 1:3~1:4 | Negative | Online Inquiry |
CDKN3 Gene Knockout Cell Lines are specifically engineered cellular models that have had the CDKN3 gene inactivated or disrupted. CDKN3, also known as cyclin-dependent kinase inhibitor 3, plays a crucial role in the regulation of the cell cycle by inhibiting cyclin-dependent kinases (CDKs), thus influencing cellular proliferation and differentiation. The knockout of this gene provides a powerful tool for researchers to study its functional role in various biological processes, particularly in cancers where dysregulation of the cell cycle is a fundamental characteristic.
The key function of the CDKN3 Gene Knockout Cell Lines is to enable the investigation of cellular responses when this particular regulatory pathway is disrupted. By using these cell lines, researchers can explore the mechanisms underlying cell cycle regulation, cellular apoptosis, and oncogenesis in a controlled environment, thus providing insight into potential therapeutic targets. The absence of CDKN3 also facilitates the analysis of compensatory mechanisms that might be activated in response to cell cycle dysregulation.
Scientifically, the importance of CDKN3 Gene Knockout Cell Lines extends into both fundamental research and clinical applications. These lines are invaluable for drug discovery and development, particularly in the evaluation of novel compounds targeting cell cycle regulators. Furthermore, they assist in the elucidation of signaling pathways implicated in various diseases, offering a critical platform for validating the role of CDKN3 in tumorigenesis and identifying biomarkers for cancer prognosis.
Compared to alternative models, such as wild-type cell lines or non-specific knockouts, our CDKN3 Gene Knockout Cell Lines provide a much more targeted approach, allowing for precision in experimentation. Each line is validated for stability and functional integrity, ensuring reliable results that enhance research outcomes.
For researchers and clinicians focused on the intricacies of cell cycle control and cancer biology, these cell lines represent a significant advance in the toolkit available for cellular studies. They provide an opportunity to uncover novel therapeutic strategies and contribute to the growing field of personalized medicine.
Our company, with its extensive expertise in genetic engineering and cell line development, is committed to providing high-quality biological products that empower researchers in their quest for scientific discovery. We are dedicated to supporting cutting-edge research with tools that drive innovation and enhance understanding in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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