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CDKAL1 Knockout Cell Lines

Gene: CDKAL1

Official Full Name: CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferaseprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18863 CDKAL1 Knockout cell line (HeLa) Human CDKAL1 1:3~1:6 Negative Online Inquiry
KO18864 CDKAL1 Knockout cell line (HCT 116) Human CDKAL1 1:2~1:4 Negative Online Inquiry
KO18865 CDKAL1 Knockout cell line (HEK293) Human CDKAL1 1:3~1:6 Negative Online Inquiry
KO18866 CDKAL1 Knockout cell line (A549) Human CDKAL1 1:3~1:4 Negative Online Inquiry

Background

CDKAL1 Gene Knockout Cell Lines are specialized cellular models characterized by the targeted disruption of the CDKAL1 gene, which is implicated in the regulation of insulin secretion and has been associated with type 2 diabetes susceptibility. These cell lines serve as invaluable tools for understanding the functionality of the CDKAL1 gene and its role in metabolic pathways, particularly those governing glucose homeostasis and beta-cell function.

The primary function of CDKAL1 Gene Knockout Cell Lines is to enable researchers to dissect the downstream effects of CDKAL1 deletion on cellular behavior. By observing changes in insulin secretion, cellular metabolism, and gene expression profiles, scientists can gain insights into the mechanistic pathways that lead to diabetes and potential therapeutic targets. The knockout approach ensures a precise elimination of the gene, facilitating the assessment of altered phenotypes in controlled experimental settings.

In research and clinical applications, these cell lines are critical for elucidating the genetic underpinnings of type 2 diabetes. They provide a platform for high-throughput screening of drug candidates aimed at enhancing beta-cell resilience or improving insulin sensitivity. Moreover, CDKAL1 Gene Knockout Cell Lines can be used in gene therapy research to explore the effects of CDKAL1 restoration as a potential corrective strategy for metabolic disorders.

One distinct advantage of using CDKAL1 Gene Knockout Cell Lines over traditional models is the specificity of gene targeting, which reduces confounding variables and enhances experimental accuracy. This specificity allows for more straightforward interpretation of results, narrowing down the effects directly attributable to CDKAL1 dysfunction.

For researchers and clinicians focusing on diabetes and related metabolic diseases, this product offers a robust model that contributes to both basic research and therapeutic advancements. The ability to manipulate and study the cellular consequences of CDKAL1 loss empowers scientists to develop targeted interventions.

Our company prides itself on providing high-quality biological products backed by rigorous validation and a commitment to advancing research in diabetes and metabolic health. With a focus on innovation and scientific excellence, we support the quest for solutions through our robust product offerings and expertise in the field.

Please note that all services are for research use only. Not intended for any clinical use.

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