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CDC42BPB Knockout Cell Lines

Gene: CDC42BPB

Official Full Name: CDC42 binding protein kinase betaprovided by HGNC

Gene Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33087 CDC42BPB Knockout cell line (HeLa) Human CDC42BPB 1:3~1:6 Negative Online Inquiry
KO33088 CDC42BPB Knockout cell line (HCT 116) Human CDC42BPB 1:2~1:4 Negative Online Inquiry
KO33089 CDC42BPB Knockout cell line (HEK293) Human CDC42BPB 1:3~1:6 Negative Online Inquiry
KO33090 CDC42BPB Knockout cell line (A549) Human CDC42BPB 1:3~1:4 Negative Online Inquiry

Background

CDC42BPB Gene Knockout Cell Lines are specialized cell lines engineered to lack the CDC42 binding protein beta (Cdc42bpβ), a critical protein implicated in various cellular processes, including cytoskeletal dynamics, cell polarity, and signal transduction pathways. These knockout models are invaluable tools in studying the functional role of Cdc42bpβ in physiological and pathological contexts, allowing researchers to elucidate its contributions to cellular organization, migration, and oncogenic processes.

The fundamental mechanism by which these cell lines operate involves the absence of Cdc42bpβ, enabling scientists to observe alterations in cellular behaviors and molecular signaling cascades. These changes can lead to important insights into disease mechanisms, particularly in cancer, where Cdc42bpβ may contribute to metastasis and tumor progression. Furthermore, the availability of these knockout cell lines facilitates investigations into potential therapeutic targets, bridging the gap between basic research and clinical applications.

The scientific importance of CDC42BPB Gene Knockout Cell Lines lies in their utility across diverse research applications, including drug discovery, mechanistic studies of diseases, and the development of novel gene therapies. Compared to traditional wild-type cell lines, the knockout variants provide a unique opportunity to dissect the specific roles of Cdc42bpβ without the confounding influence of its function, making them superior for targeted experiments.

Additionally, these cell lines offer distinct advantages over alternative methods, such as transient transfection or chemical inhibition, by providing a stable and consistent model for long-term studies. They are particularly valued by researchers and clinicians who require reproducible and robust systems that mirror in vivo conditions, thus accelerating the pace of exploration in cellular biology.

By investing in CDC42BPB Gene Knockout Cell Lines, users gain access to a cutting-edge product developed by our company, which specializes in providing high-quality biological tools derived from rigorous scientific research. Our expertise in genetic engineering and commitment to advancing cellular biology underscores the reliability and value of our products, ensuring that researchers and clinicians can effectively push the boundaries of scientific inquiry.

Please note that all services are for research use only. Not intended for any clinical use.

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