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CDC25B Knockout Cell Lines

Gene: CDC25B

Official Full Name: cell division cycle 25Bprovided by HGNC

Gene Summary: CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10891 CDC25B Knockout cell line (HeLa) Human CDC25B 1:3~1:6 Negative Online Inquiry
KO10892 CDC25B Knockout cell line (HCT 116) Human CDC25B 1:2~1:4 Negative Online Inquiry
KO10893 CDC25B Knockout cell line (HEK293) Human CDC25B 1:3~1:6 Negative Online Inquiry
KO10894 CDC25B Knockout cell line (A549) Human CDC25B 1:3~1:4 Negative Online Inquiry

Background

CDC25B Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to disrupt the expression of the CDC25B gene, which encodes a key phosphatase involved in the regulation of the cell cycle. This product allows researchers to explore the functional role of CDC25B in cellular processes, particularly its influence on mitosis and overall cell proliferation. By utilizing these knockout cell lines, scientists can study the consequences of CDC25B deficiency on cellular behavior, providing insights into its mechanisms of action.

The primary function of these cell lines is to enable the investigation of CDC25B's impact on cell cycle checkpoints, DNA repair mechanisms, and oncogenesis. The knockout of CDC25B leads to a complex response in cellular signaling pathways, enabling researchers to decipher its contributions to tumorigenesis and potential therapeutic targets for cancer treatment. This cellular model serves not only in the study of fundamental cell biology but also in drug development, where understanding the nuances of CDC25B inhibition can guide the creation of novel anti-cancer therapies.

Significantly, CDC25B Gene Knockout Cell Lines stand out due to their precise gene editing, allowing for reproducible and robust experimental results. Unlike alternative models that may only partially inhibit gene function, these knockout lines provide a complete absence of CDC25B expression, allowing for clearer interpretations of experimental outcomes. This specificity ensures that findings are directly attributable to the targeted gene loss, thereby enhancing the reliability of conclusions drawn from studies.

For researchers and clinicians working in cancer biology and therapeutics, these cell lines represent critical tools in elucidating complex cellular responses and advancing understanding in the fight against malignancies. The insights gained from using CDC25B knockout models can help identify biomarkers for disease progression and potential therapeutic avenues.

Our company specializes in cutting-edge genetic engineering technologies that facilitate the development of high-quality research tools like CDC25B Gene Knockout Cell Lines. With extensive expertise in gene editing and cellular models, we are committed to providing the scientific community with reliable products that drive innovation and discovery in biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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