Gene: CCR10
Official Full Name: C-C motif chemokine receptor 10provided by HGNC
Gene Summary: Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03529 | CCR10 Knockout cell line (HeLa) | Human | CCR10 | 1:3~1:6 | Negative | Online Inquiry |
KO03530 | CCR10 Knockout cell line (HEK293) | Human | CCR10 | 1:3~1:6 | Negative | Online Inquiry |
CCR10 Gene Knockout Cell Lines are meticulously engineered cellular models that exhibit a complete loss of the CCR10 gene, which encodes a chemokine receptor critical for immune system function and inflammatory responses. By utilizing CRISPR-Cas9 technology, these cell lines enable precise elucidation of the CCR10 signaling pathways and their implications in various physiological and pathological conditions.
The primary function of CCR10 involves mediating the migration of specific immune cells to sites of inflammation, particularly in response to skin-homing chemokines. These knockout cell lines allow researchers to investigate alterations in cellular behavior, migration patterns, and immune response dynamics when CCR10 is absent. The result is a powerful tool for deciphering the role of CCR10 in diseases such as atopic dermatitis, psoriasis, and other inflammatory disorders.
In scientific research and clinical applications, the CCR10 Gene Knockout Cell Lines provide unprecedented insights into immune modulation and therapeutic targeting. By allowing for studies that assess the receptor's role in immune cell trafficking and function, these models facilitate the development of new strategies for treating chronic inflammatory diseases and guiding drug discovery.
Furthermore, the unique selling point of our CCR10 Gene Knockout Cell Lines lies in their high specificity and reliability compared to traditional knockout methods, which may result in off-target effects and inconsistent results. Researchers benefit from the rigorous validation accompanying our cell lines, ensuring reproducibility and accuracy in their experiments.
In summary, the CCR10 Gene Knockout Cell Lines are invaluable assets for those working in immunology, drug development, and translational medicine. They empower researchers and clinicians to further their understanding of immune responses and contribute to innovative therapeutic advancements. Our company, with its extensive expertise in advanced genetic engineering and cellular model development, is committed to providing high-quality biological products that drive scientific progress.
Please note that all services are for research use only. Not intended for any clinical use.
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