Gene: CCNT2
Official Full Name: cyclin T2provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02765 | CCNT2 Knockout cell line (HeLa) | Human | CCNT2 | 1:3~1:6 | Negative | Online Inquiry |
KO02766 | CCNT2 Knockout cell line (HCT 116) | Human | CCNT2 | 1:2~1:4 | Negative | Online Inquiry |
KO02767 | CCNT2 Knockout cell line (HEK293) | Human | CCNT2 | 1:3~1:6 | Negative | Online Inquiry |
KO02768 | CCNT2 Knockout cell line (A549) | Human | CCNT2 | 1:3~1:4 | Negative | Online Inquiry |
CCNT2 Gene Knockout Cell Lines represent a pivotal advancement in the field of genetic research, specifically designed to study the functional role of the cyclin T2 gene (CCNT2) in various biological processes. These cell lines have been meticulously engineered to exhibit a complete knockout of the CCNT2 gene, allowing researchers to observe the effects of its absence on cellular behavior, signaling pathways, and gene expression regulation.
The functional capacity of CCNT2 lies in its critical involvement as a co-activator within the transcriptional machinery. By facilitating the interaction between cyclin-dependent kinases (CDKs) and RNA polymerase II, CCNT2 plays a significant role in transcriptional initiation and elongation. Knocking out this gene provides a model system for elucidating its roles in cellular activities such as proliferation, differentiation, and response to stress.
The scientific importance of CCNT2 Gene Knockout Cell Lines extends to a diverse range of applications, from basic research aimed at understanding the underlying mechanisms of gene regulation to translational studies that may highlight therapeutic targets for diseases where CCNT2 is implicated, such as certain cancers or genetic disorders. These cell lines are particularly valuable for high-throughput screening, drug discovery, and functional genomics studies.
Compared to alternative gene editing techniques or cell lines, the CCNT2 Gene Knockout Cell Lines are characterized by their specificity and reproducibility. Unlike transient knockdown methods that may lead to off-target effects, these lines provide consistent and stable gene editing, allowing for reliable experimental outcomes. Additionally, the availability of extensive characterization data ensures researchers can confidently utilize these cell lines in various experimental contexts.
Researchers and clinicians benefit immensely from the CCNT2 Gene Knockout Cell Lines as they facilitate groundbreaking insights into gene function and disease mechanisms. By harnessing this innovative model, scientists can more effectively explore the complex interactions within the cellular environment.
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