Gene: CCNC
Official Full Name: cyclin Cprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38659 | CCNC Knockout cell line (HeLa) | Human | CCNC | 1:3~1:6 | Negative | Online Inquiry |
KO38660 | CCNC Knockout cell line (HCT 116) | Human | CCNC | 1:2~1:4 | Negative | Online Inquiry |
KO38661 | CCNC Knockout cell line (HEK293) | Human | CCNC | 1:3~1:6 | Negative | Online Inquiry |
KO38662 | CCNC Knockout cell line (A549) | Human | CCNC | 1:3~1:4 | Negative | Online Inquiry |
CCNC Gene Knockout Cell Lines are specially engineered cell lines in which the CCNC gene, a crucial component of the cyclin family involved in regulating the cell cycle, has been effectively disrupted. This knockout model enables researchers to dissect the role of CCNC in various cellular processes, from proliferation to apoptosis, providing a deeper understanding of its impact on cellular functions and interactions.
These cell lines function by utilizing CRISPR-Cas9 technology, which allows for precise editing of the genome. The targeted deletion of the CCNC gene leads to observable phenotypic changes that can be quantified, offering insights into how cyclin-dependent pathways operate under normal versus altered conditions. The functionality of these cell lines is fundamental in elucidating the intricate web of regulatory mechanisms that control cell cycle progression, and their role in oncogenesis, as dysregulation of cyclins is often implicated in cancer.
The scientific importance of CCNC Gene Knockout Cell Lines lies in their diverse applications in both research and clinical settings. They serve as pivotal tools for drug development, allowing for the identification of novel therapeutic targets and the testing of pharmaceutical agents. Additionally, they facilitate the investigation of disease mechanisms and the validation of biomarkers related to cell cycle dysregulation.
What sets these cell lines apart from traditional knockout methods is their precision and the reproducibility of results, ensuring reliable data that researchers can depend upon. Moreover, they come with extensive documentation detailing their characterization, providing users with valuable contexts for their experimental designs.
The value of CCNC Gene Knockout Cell Lines to researchers and clinicians cannot be overstated; they offer a sophisticated model for advancing our understanding of cell cycle dynamics and their implications in health and disease. With our company’s dedication to high-quality biological products and extensive expertise in genetic engineering, we are proud to provide this model system, contributing to the ongoing pursuit of innovations in biomedical research.
Please note that all services are for research use only. Not intended for any clinical use.
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