Gene: CCL20
Official Full Name: C-C motif chemokine ligand 20provided by HGNC
Gene Summary: This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08333 | CCL20 Knockout cell line (HEK293) | Human | CCL20 | 1:3~1:6 | Negative | Online Inquiry |
KO08334 | CCL20 Knockout cell line (A549) | Human | CCL20 | 1:3~1:4 | Negative | Online Inquiry |
CCL20 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the CCL20 gene, which encodes the chemokine CCL20, known for its pivotal role in immune responses and inflammation. These genetically modified cell lines have had the CCL20 gene disrupted through targeted gene editing techniques such as CRISPR-Cas9, allowing researchers to observe the effects of its absence in various biological contexts.
The primary function of CCL20 is to recruit immune cells to sites of inflammation, thus making it a critical player in immune surveillance and response. The knockout of this gene enables researchers to investigate its contributions to pathophysiological conditions, including autoimmune diseases, allergies, and cancer metastasis. By utilizing these knockout cell lines, scientists can delineate the signaling pathways activated by CCL20 and assess its involvement in chemotaxis and cell migration.
In research and clinical settings, CCL20 Gene Knockout Cell Lines represent a valuable tool for elucidating the molecular mechanisms underpinning immune responses. They offer insights that could lead to the development of novel therapeutic strategies aimed at modulating immune responses in various diseases. These cell lines are also crucial in preclinical studies, allowing for the evaluation of potential drug candidates that may target the pathways associated with CCL20.
What sets our CCL20 Gene Knockout Cell Lines apart from other available models is the precision and reliability achieved through our rigorous quality control standards. With a focus on reproducibility, our lines are validated for consistent performance in various assays, ensuring that researchers can trust the results they obtain.
For researchers and clinicians aiming to advance their understanding of immune regulation, these knockout cell lines provide a unique opportunity to explore groundbreaking hypotheses and generate data that can translate into impactful clinical applications. With years of expertise in developing innovative biological products, our company is committed to supporting the scientific community with high-quality tools that drive discovery and enhance research outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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