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CCDC22 Knockout Cell Lines

Gene: CCDC22

Official Full Name: CCC complex scaffolding subunit CCDC22provided by HGNC

Gene Summary: This gene encodes a protein containing a coiled-coil domain. The encoded protein functions in the regulation of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) by interacting with COMMD (copper metabolism Murr1 domain-containing) proteins. The mouse orthologous protein has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. This human gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability. [provided by RefSeq, Aug 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27306 CCDC22 Knockout cell line (HeLa) Human CCDC22 1:3~1:6 Negative Online Inquiry
KO27307 CCDC22 Knockout cell line (HCT 116) Human CCDC22 1:2~1:4 Negative Online Inquiry
KO27308 CCDC22 Knockout cell line (HEK293) Human CCDC22 1:3~1:6 Negative Online Inquiry
KO27309 CCDC22 Knockout cell line (A549) Human CCDC22 1:3~1:4 Negative Online Inquiry

Background

CCDC22 Gene Knockout Cell Lines represent a transformative addition to the toolbox of researchers exploring gene function and disease mechanisms. CCDC22, or Coiled-Coil Domain Containing 22, is implicated in the regulation of cellular processes, including ciliogenesis and cellular signaling pathways. The knockout cell lines are engineered using CRISPR-Cas9 technology, which allows for precise edits to the genome, enabling the complete disruption of the CCDC22 gene. This specificity makes them invaluable for dissecting the roles of CCDC22 in various biological contexts, providing insights into its involvement in both normal physiology and pathological conditions.

These cell lines function as critical models for studying the downstream effects of CCDC22 loss, especially in the context of diseases associated with ciliary dysfunction, such as primary ciliary dyskinesia and polycystic kidney disease. Researchers can utilize these knockout lines to perform assays that elucidate cellular responses, protein interactions, and gene expression changes in the absence of functional CCDC22. The ability to create tailored experiments centered on a single gene knockout allows for accelerated discovery in both fundamental biology and drug development.

One significant advantage of CCDC22 Gene Knockout Cell Lines is their versatility compared to traditional cell models, which may contain confounding variables. Our product offers enhanced reproducibility and specificity in studies focused on genetic pathways, providing researchers with clearer insights and more reliable data. Additionally, these cell lines can serve diverse applications, including pharmacological testing, high-throughput screening, and the study of oncogenic pathways, making them suitable for a wide range of research disciplines.

For both researchers and clinicians keen on advancing their understanding of gene function and developing therapeutic strategies, CCDC22 Gene Knockout Cell Lines offer a streamlined model that enhances experimental rigor and data relevance. By leveraging our expert knowledge in genetic engineering and cell line development, our company provides high-quality biological products that drive innovation and success in scientific inquiry. With a commitment to excellence and continuous improvement, we ensure that our offerings meet the highest standards of quality and reliability essential for cutting-edge research.

Please note that all services are for research use only. Not intended for any clinical use.

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