Gene: CCDC186
Official Full Name: coiled-coil domain containing 186provided by HGNC
Gene Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in vesicle cytoskeletal trafficking. Predicted to act upstream of or within insulin secretion involved in cellular response to glucose stimulus and response to bacterium. Predicted to be located in Golgi apparatus. Predicted to be active in trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18937 | CCDC186 Knockout cell line (HeLa) | Human | CCDC186 | 1:3~1:6 | Negative | Online Inquiry |
KO18938 | CCDC186 Knockout cell line (HCT 116) | Human | CCDC186 | 1:2~1:4 | Negative | Online Inquiry |
KO18939 | CCDC186 Knockout cell line (HEK293) | Human | CCDC186 | 1:3~1:6 | Negative | Online Inquiry |
KO18940 | CCDC186 Knockout cell line (A549) | Human | CCDC186 | 1:3~1:4 | Negative | Online Inquiry |
CCDC186 Gene Knockout Cell Lines are genetically modified cellular models designed to investigate the functional consequences of the CCDC186 gene deletion. These knockout cell lines provide a powerful platform for researchers to study the role of CCDC186, a gene implicated in various biological processes, including cell proliferation, differentiation, and response to cellular stress. By completely disrupting the gene's expression, these cell lines facilitate the elucidation of pathways affected by CCDC186 loss and contribute to understanding the gene's potential involvement in disease mechanisms.
The key mechanism underlying the functionality of CCDC186 knockout cell lines lies in CRISPR/Cas9 gene-editing technology, which enables precise genomic modifications. This innovative approach allows for the creation of specific knockouts with high efficiency and minimal off-target effects. As a result, researchers can generate reliable experimental models that reflect the physiological relevance of CCDC186 inhibition, thereby providing valuable insights into cellular behavior and gene function.
Scientifically, CCDC186 knockout cell lines are crucial for advancing research in fields such as cancer biology, where aberrations in gene expression are frequently observed. They can facilitate high-throughput screening for potential therapeutic agents, contribute to drug development studies, and shed light on the molecular mechanisms driving tumorigenesis or other pathologies related to CCDC186 dysregulation. This utility extends to personalized medicine, where understanding gene function may inform targeted treatment strategies.
A significant advantage of CCDC186 knockout cell lines over alternative models is their specificity and the fidelity with which they mimic the native biological context. Unlike transient knockdown methods that may yield variable results, these stable knockout cell lines provide consistent and reproducible data, essential for rigorous scientific inquiry. Additionally, their versatility allows for the integration of various experimental techniques such as CRISPR-mediated gene therapy, enabling researchers to explore a range of applications from basic science to therapeutic development.
The value of CCDC186 Gene Knockout Cell Lines is compelling for researchers, clinicians, and pharmaceutical entities alike, as they offer an unparalleled resource for investigating gene function and drug response in a controlled environment. With these cell lines, researchers can decipher complex biological questions with greater confidence, leading to advancements in therapeutic strategies and improving patient outcomes.
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Please note that all services are for research use only. Not intended for any clinical use.
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