Gene: CCDC137
Official Full Name: coiled-coil domain containing 137provided by HGNC
Gene Summary: Enables RNA binding activity. Located in chromosome and fibrillar center. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01973 | CCDC137 Knockout cell line (HeLa) | Human | CCDC137 | 1:3~1:6 | Negative | Online Inquiry |
KO01974 | CCDC137 Knockout cell line (HCT 116) | Human | CCDC137 | 1:2~1:4 | Negative | Online Inquiry |
KO01975 | CCDC137 Knockout cell line (HEK293) | Human | CCDC137 | 1:3~1:6 | Negative | Online Inquiry |
KO01976 | CCDC137 Knockout cell line (A549) | Human | CCDC137 | 1:3~1:4 | Negative | Online Inquiry |
CCDC137 Gene Knockout Cell Lines are specifically engineered cellular models that allow for the precise study of the CCDC137 gene's function and its associated pathways. Utilizing advanced CRISPR-Cas9 gene editing technology, these cell lines have been developed to provide researchers with a reliable tool to investigate the biological implications of CCDC137 loss-of-function, offering insights into its role in cellular processes including motility, proliferation, and differentiation.
The mechanism of action involves the targeted disruption of CCDC137 through the insertion of a double-strand break by the Cas9 nuclease, leading to frameshift mutations upon repair. This targeted knockout facilitates a comprehensive understanding of the gene's contributions to various physiological and pathological conditions, making it invaluable for functional genomics studies. Researchers can observe the resultant phenotypic changes and dysregulation of signaling pathways, thereby elucidating the potential correlations of CCDC137 with diseases.
The scientific importance of CCDC137 Gene Knockout Cell Lines extends into both research and clinical applications, particularly in the areas of cancer biology, genetic disorders, and regenerative medicine. These cell lines serve as a platform for drug screening and biomarker discovery, providing critical data that can influence therapeutic strategies in clinical settings.
One of the distinctive advantages of CCDC137 Gene Knockout Cell Lines is their high specificity and efficiency in gene editing compared to conventional knockdown methods such as RNA interference, which may not completely abrogate gene function. Moreover, the knockout approach ensures a more stable and permanent alteration, enabling long-term studies on gene function and drug response.
For researchers and clinicians looking for robust, reproducible results, our CCDC137 Gene Knockout Cell Lines represent a cutting-edge solution that empowers them to push the boundaries of current scientific inquiry. With our commitment to producing high-quality biological products and our expertise in gene editing technologies, we are dedicated to supporting the advancement of life sciences through innovative research tools.
Please note that all services are for research use only. Not intended for any clinical use.
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