Gene: CCAR1
Official Full Name: cell division cycle and apoptosis regulator 1provided by HGNC
Gene Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; nuclear receptor coactivator activity; and transcription corepressor activity. Involved in positive regulation of cell migration and positive regulation of cell population proliferation. Acts upstream of or within positive regulation of apoptotic process. Located in nuclear envelope lumen. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00978 | CCAR1 Knockout cell line (HCT 116) | Human | CCAR1 | Negative | Online Inquiry | |
KO06455 | CCAR1 Knockout cell line (HeLa) | Human | CCAR1 | 1:3~1:6 | Negative | Online Inquiry |
KO06456 | CCAR1 Knockout cell line (HEK293) | Human | CCAR1 | 1:3~1:6 | Negative | Online Inquiry |
KO06457 | CCAR1 Knockout cell line (A549) | Human | CCAR1 | 1:3~1:4 | Negative | Online Inquiry |
CCAR1 Gene Knockout Cell Lines are specialized cellular models designed for the targeted deletion of the CCAR1 (Cell Cycle and Apoptosis Regulation 1) gene. These cell lines are invaluable tools for researchers exploring cellular mechanisms related to cell cycle regulation, apoptosis, and various pathophysiological conditions, including cancer and autoimmune diseases. By facilitating the elucidation of the role of CCAR1 in critical biological pathways, these knockouts help in the identification of therapeutic targets and the development of innovative treatment strategies.
The primary function of CCAR1 Gene Knockout Cell Lines is to provide a platform for studying the consequences of complete CCAR1 gene loss. These cell lines utilize CRISPR/Cas9 technology, allowing for precise and efficient genome editing. The knockout of the CCAR1 gene leads to notable alterations in cell proliferation, differentiation, and survival pathways, enabling comprehensive investigation into how CCAR1 functions as a regulator of gene expression and cellular stress responses.
In research and clinical settings, these cell lines have significant applications in drug development, molecular biology studies, and pathology investigations. By enabling the evaluation of CCAR1's contributions to tumor growth and metastasis, they can elucidate potential biomarkers for patient stratification and treatment personalization. Furthermore, CCAR1 gene knockouts can serve as models for understanding autoimmune disorders, providing insights that can aid in the development of targeted therapies.
Compared to traditional knockdown methods, such as RNA interference (RNAi), CCAR1 Gene Knockout Cell Lines offer permanent and stable gene disruptions with reproducible phenotypic outcomes. This stability, combined with the precise engineering afforded by CRISPR/Cas9, minimizes off-target effects and ensures a more reliable experimental framework for investigators.
For researchers and clinicians, leveraging CCAR1 Gene Knockout Cell Lines enhances the ability to uncover novel insights into the molecular dynamics of disease processes. The specificity of this tool empowers nuanced studies that translate into meaningful advancements in science and medicine.
Our company is committed to advancing biological research through high-quality, rigorously validated products. With deep expertise in gene editing technologies and a dedication to supporting the scientific community, we offer a diverse array of cellular models tailored to meet the evolving needs of researchers in academia and industry.
Please note that all services are for research use only. Not intended for any clinical use.
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