Gene: CBLB
Official Full Name: Cbl proto-oncogene Bprovided by HGNC
Gene Summary: This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00142 | CBLB Knockout cell line (HEK293) | Human | CBLB | 1:3~1:6 | Negative | Online Inquiry |
KO38667 | CBLB Knockout cell line (HeLa) | Human | CBLB | 1:3~1:6 | Negative | Online Inquiry |
KO38668 | CBLB Knockout cell line (HCT 116) | Human | CBLB | 1:2~1:4 | Negative | Online Inquiry |
KO38669 | CBLB Knockout cell line (A549) | Human | CBLB | 1:3~1:4 | Negative | Online Inquiry |
CBLB Gene Knockout Cell Lines are specialized cell models generated through precise genetic engineering techniques to eliminate the expression of the CBLB gene. This gene plays a critical role in immune regulation and signal transduction pathways, particularly in the context of immune responses and cancer biology. By knocking out this gene, researchers can study the functional implications of CBLB silencing on cellular behavior, including proliferation, differentiation, and apoptosis.
The key function of these knockout cell lines lies in their ability to serve as effective tools for understanding the roles of the CBLB gene in various biological processes. The knockout mechanism employs CRISPR-Cas9 or other gene-editing technologies, ensuring a high degree of specificity and efficiency in the disruption of target gene function. Researchers can leverage these models to dissect molecular pathways and examine the downstream effects of CBLB absence, ultimately contributing to our understanding of immune system dysregulation and tumorigenesis.
The scientific importance of CBLB Gene Knockout Cell Lines is evident in their applications within both basic and translational research. They can be used in drug discovery, functional genomics studies, and the development of therapeutic strategies targeting immune-related disorders and cancers. By offering insights into genetic interactions and pathway dependencies, these cell lines facilitate the identification of novel biomarkers and therapeutic targets.
What sets CBLB Gene Knockout Cell Lines apart from traditional cell models is the precision of the genetic engineering approach, which minimizes off-target effects and enhances the reproducibility of experimental results. This high specificity, combined with the accelerated pace of research enabled by these models, makes them an invaluable resource for scientists aiming to unravel complex biological questions.
For researchers and clinicians, the value of these knockout cell lines lies in their ability to provide clearer, more reliable data that inform the development of innovative therapies and enhance our understanding of disease mechanisms. Our company specializes in providing high-quality, ready-to-use biological products that support cutting-edge research, ensuring that scientists can rely on our expertise and commitment to advancing the field.
Please note that all services are for research use only. Not intended for any clinical use.
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