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CAV1 Knockout Cell Lines

Gene: CAV1

Official Full Name: caveolin 1provided by HGNC

Gene Summary: The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00459 CAV1 gRNA3-gRNA4 KO plasmid CAV1 $850
GP00504 CAV1 gRNA1-gRNA2 KO plasmid CAV1 $850
KO00547 CAV1 Knockout cell line (HEK293) Human CAV1 1:3~1:6 Negative Online Inquiry
KO00750 CAV1 Knockout cell line(MCF7) Human CAV1 1:2~1:4 Negative Online Inquiry
KO09732 CAV1 Knockout cell line (HeLa) Human CAV1 1:3~1:6 Negative Online Inquiry
KO09733 CAV1 Knockout cell line (HCT 116) Human CAV1 1:2~1:4 Negative Online Inquiry
KO09734 CAV1 Knockout cell line (A549) Human CAV1 1:3~1:4 Negative Online Inquiry

Background

CAV1 Gene Knockout Cell Lines are specifically engineered cellular models designed for research that targets the caveolin-1 gene (CAV1), a critical component in cellular signaling and membrane dynamics. These knockout cell lines have been developed using advanced CRISPR/Cas9 gene-editing technology to provide a reliable platform for studying the functional implications of CAV1 deletion on various physiological processes.

The primary function of CAV1 is its involvement in caveolae formation, which plays a crucial role in lipid regulation, endocytosis, and signal transduction pathways. By utilizing our CAV1 Gene Knockout Cell Lines, researchers can explore how the absence of CAV1 affects processes such as tumor progression, metabolic disorders, and cardiovascular diseases. The knockout models enable precise examination of molecular mechanisms underlying these conditions, providing valuable insights that can inform therapeutic development.

The scientific importance of CAV1 knockout models extends to both basic and applied research. In clinical settings, these cell lines serve as valuable tools for drug discovery and toxicity testing, enabling better assessment of pharmacological agents targeting caveolae-associated pathways. Furthermore, these models can be used to validate biomarker candidates, leading to new diagnostic methods or treatment options.

Compared to traditional cell lines that retain functional CAV1, our CAV1 Gene Knockout Cell Lines offer clear advantages, including enhanced reproducibility of experimental results and a focused approach to studying caveolae-mediated processes. Researchers benefit from a more straightforward interpretation of data, leading to innovative discoveries.

With years of expertise in developing specialized cellular models, our company ensures that customers receive high-quality biological products that meet their research needs. By choosing our CAV1 Gene Knockout Cell Lines, researchers and clinicians gain access to cutting-edge tools designed to propel scientific inquiry and ultimately advance medical knowledge and patient care.

Please note that all services are for research use only. Not intended for any clinical use.

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