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CATSPER3 Knockout Cell Lines

Gene: CATSPER3

Official Full Name: cation channel sperm associated 3provided by HGNC

Gene Summary: Predicted to enable voltage-gated calcium channel activity. Predicted to be involved in flagellated sperm motility; sodium ion transport; and sperm capacitation. Predicted to act upstream of or within establishment of localization in cell. Predicted to be located in plasma membrane. Predicted to be part of CatSper complex. Predicted to be active in acrosomal vesicle. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19059 CATSPER3 Knockout cell line (HCT 116) Human CATSPER3 1:2~1:4 Negative Online Inquiry
KO19060 CATSPER3 Knockout cell line (HEK293) Human CATSPER3 1:3~1:6 Negative Online Inquiry
KO19061 CATSPER3 Knockout cell line (A549) Human CATSPER3 1:3~1:4 Negative Online Inquiry

Background

CATSPER3 Gene Knockout Cell Lines are a specialized biological product designed to facilitate research into the function and pathology of the CATSPER3 gene, which is crucial for sperm motility and fertility in male mammals. These knockout cell lines are generated using cutting-edge CRISPR/Cas9 gene-editing technology, whereby the CATSPER3 gene is intentionally disrupted, allowing for the study of the resultant phenotypic changes in cellular behavior and function.

The primary function of the CATSPER3 gene is to encode a protein that forms part of the calcium-permeable ion channel specifically expressed in sperm. This ion channel is critical for the regulation of calcium influx, which is necessary for the activation and motility of sperm cells. By utilizing these knockout cell lines, researchers can investigate the underlying cellular mechanisms that govern sperm function and male fertility, as well as the potential implications of CATSPER3 mutations in infertility disorders.

The scientific importance of CATSPER3 Gene Knockout Cell Lines cannot be understated, as they provide essential insights into reproductive biology, potentially leading to advancements in infertility treatments and contraceptive methods. These cell lines are invaluable tools for toxicology studies, drug screening, and the investigation of gene function in reproductive physiology, making them a critical asset in both academic and clinical research settings.

In comparison to traditional knockout models, CATSPER3 Gene Knockout Cell Lines offer several advantages, including a more straightforward and quicker approach for functional assays, reduced animal usage, and the ability to conduct high-throughput screening. These features enhance experimental reproducibility and facilitate a more thorough exploration of the CATSPER3 gene's role in semen quality and reproductive health.

For researchers and clinicians focused on reproductive health, the value of CATSPER3 Gene Knockout Cell Lines lies in their unique capacity to provide a clear model of male fertility issues, driving forward innovative solutions and therapeutic strategies. Our company prides itself on its expertise in the development and production of high-quality biological products, ensuring that our offerings are reliably effective and scientifically robust for advancing research in reproductive biology.

Please note that all services are for research use only. Not intended for any clinical use.

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