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CAT Knockout Cell Lines

Gene: CAT

Official Full Name: catalaseprovided by HGNC

Gene Summary: This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08154 CAT Knockout cell line (HeLa) Human CAT 1:3~1:6 Negative Online Inquiry
KO08155 CAT Knockout cell line (HCT 116) Human CAT 1:2~1:4 Negative Online Inquiry
KO08156 CAT Knockout cell line (HEK293) Human CAT 1:3~1:6 Negative Online Inquiry
KO08157 CAT Knockout cell line (A549) Human CAT 1:3~1:4 Negative Online Inquiry

Background

CAT Gene Knockout Cell Lines are precisely engineered cellular models that have been developed to facilitate the study of the CAT (catalase) gene, which plays a crucial role in cellular oxidative stress responses. These knockout cell lines are created through advanced genome editing technologies such as CRISPR-Cas9, allowing for the specific and permanent deletion of the CAT gene. By eliminating catalase, a key enzyme that decomposes hydrogen peroxide into water and oxygen, researchers can investigate the biological consequences of oxidative stress within a controlled environment.

The primary mechanism by which these cell lines function is through enhanced cellular susceptibility to oxidative damage, enabling studies on the implications of reduced catalase activity in various disease mechanisms, such as neurodegeneration, cancer, and metabolic disorders. By utilizing CAT Gene Knockout Cell Lines, researchers can explore the cellular pathways affected by oxidative stress, leading to a deeper understanding of cellular survival mechanisms and disease pathology.

In research and clinical settings, these cell lines serve as invaluable tools for drug discovery and validation, enabling the testing of antioxidant therapies and the evaluation of potential therapeutic agents that target oxidative stress pathways. Unlike traditional models, the CAT Gene Knockout Cell Lines eliminate variables linked to catalase function, providing a more accurate representation of conditions where oxidative stress plays a pivotal role.

One of the standout advantages of CAT Gene Knockout Cell Lines is their reproducibility and reliability, which are critical for producing consistent experimental results. Additionally, their unique capability to model specific aspects of oxidative stress distinguishes them from other knockouts that may not focus on catalase, giving researchers a targeted approach to elucidating the role of oxidative stress in various biological contexts.

For researchers and clinicians, these cell lines represent a significant advancement in experimental design, offering the ability to dissect complex biological processes. Their application is vital for developing new therapeutic strategies, potentially leading to breakthroughs in treating oxidation-related diseases.

Our company, with its expertise in cell line engineering and commitment to scientific advancement, is proud to provide these cutting-edge CAT Gene Knockout Cell Lines, enabling the research community to explore new frontiers in oxidative stress and cellular response mechanisms.

Please note that all services are for research use only. Not intended for any clinical use.

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