Gene: CASP6
Official Full Name: caspase 6provided by HGNC
Gene Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01408 | CASP6 Knockout cell line(HeLa) | Human | CASP6 | 1:3~1:6 | Negative | Online Inquiry |
KO19070 | CASP6 Knockout cell line (HCT 116) | Human | CASP6 | 1:2~1:4 | Negative | Online Inquiry |
KO19071 | CASP6 Knockout cell line (HEK293) | Human | CASP6 | 1:3~1:6 | Negative | Online Inquiry |
KO19072 | CASP6 Knockout cell line (A549) | Human | CASP6 | 1:3~1:4 | Negative | Online Inquiry |
CASP6 Gene Knockout Cell Lines are custom-engineered cellular models designed to study the role of the CASP6 gene in cellular apoptosis and disease-related processes. This product offers a unique means to investigate the molecular mechanisms underlying programmed cell death, neurodegenerative conditions, and various cancer types. By utilizing CRISPR/Cas9 technology, CASP6 is precisely disrupted, allowing researchers to analyze the functional consequences of this gene knockout in a controlled environment.
The primary function of CASP6 in cellular systems is its role as an executioner caspase in the apoptotic cascade, critical for maintaining cellular homeostasis. When CASP6 is knocked out, researchers can observe alterations in apoptotic signaling pathways and assess how these changes impact cellular responses to stressors or therapeutic agents. This provides invaluable insight for understanding the molecular basis of diseases where apoptosis plays a vital role, offering potential targets for intervention in clinical settings.
The scientific importance of CASP6 Gene Knockout Cell Lines extends to their applications in drug discovery and development, biomarker identification, and the exploration of genetic susceptibility to diseases. These cell lines empower researchers to elucidate how CASP6 modulation can affect the efficacy of potential therapeutics, particularly in oncology and neurobiology, where controlled apoptosis is crucial.
Compared to other cell line models, CASP6 Gene Knockout Cell Lines come with the advantage of specificity and robustness due to their targeted gene disruption. This specificity reduces off-target effects and enhances reproducibility, allowing for more accurate simulation of disease mechanisms.
For researchers, clinicians, and pharmaceutical companies, the use of these specialized cell lines can significantly enhance the understanding of apoptotic processes and the development of new therapeutic strategies. Utilizing CASP6 Gene Knockout Cell Lines allows for a clear, detailed exploration of apoptosis-related activities and interactions, paving the way for innovative treatments.
Our company prides itself on leading advancements in biological products by providing high-quality, customizable solutions that cater to the unique needs of the scientific community. With our expertise in genetic engineering and cell line development, we are committed to supporting researchers in their quest for groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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