Gene: CASK
Official Full Name: calcium/calmodulin dependent serine protein kinaseprovided by HGNC
Gene Summary: This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, intellectual disability and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked intellectual disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00454 | CASK Knockout cell line (A549) | Human | CASK | 1:3~1:4 | Negative | Online Inquiry |
KO34039 | CASK Knockout cell line (HeLa) | Human | CASK | 1:3~1:6 | Negative | Online Inquiry |
KO34040 | CASK Knockout cell line (HCT 116) | Human | CASK | 1:2~1:4 | Negative | Online Inquiry |
KO34041 | CASK Knockout cell line (HEK293) | Human | CASK | 1:3~1:6 | Negative | Online Inquiry |
CASK Gene Knockout Cell Lines are specialized cellular models engineered to specifically disrupt the CASK gene, which encodes for a protein crucial to various neurobiological processes, including synaptic function and neuronal development. These genetically modified cell lines utilize advanced CRISPR-Cas9 technology to achieve a complete knockout of the CASK gene, enabling researchers to study the consequent phenotypic and molecular changes in a controlled environment.
The primary function of these knockout cell lines lies in their ability to elucidate the roles of CASK in cell signaling, protein interaction, and neurodevelopmental disorders. By observing the alterations in cellular behaviors, such as differentiation, proliferation, and signaling pathways associated with synaptic transmission, researchers can gain insights into the pathophysiology of conditions like intellectual disability and autism spectrum disorders.
The scientific importance of CASK Gene Knockout Cell Lines extends beyond basic research, making them invaluable in translational medicine. They serve as a crucial tool in screening potential therapeutic compounds, modeling diseases relevant to human health, and interpreting the genetic basis of neurologic conditions. Researchers and clinicians can leverage these models to validate hypotheses regarding CASK’s role in neural circuits and assess the efficacy of new treatment strategies.
Compared to alternative gene knockout technologies, our CASK Gene Knockout Cell Lines offer highly efficient targeting and consistent results, reducing the variability commonly associated with other gene disruption methods. Additionally, these cell lines are readily available and easy to culture, allowing for seamless integration into existing research workflows.
The value of CASK Gene Knockout Cell Lines lies in their ability to drive discoveries that translate into better understanding and treatment options for neurodevelopmental disorders. Researchers and clinicians aiming to explore the functions linked to the CASK gene will find these models indispensable.
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Please note that all services are for research use only. Not intended for any clinical use.
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