Gene: C18orf54
Official Full Name: chromosome 18 open reading frame 54provided by HGNC
Gene Summary: Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO19143 | C18orf54 Knockout cell line (HeLa) | Human | C18orf54 | 1:3~1:6 | Negative | Online Inquiry |
KO19144 | C18orf54 Knockout cell line (HCT 116) | Human | C18orf54 | 1:2~1:4 | Negative | Online Inquiry |
KO19145 | C18orf54 Knockout cell line (HEK293) | Human | C18orf54 | 1:3~1:6 | Negative | Online Inquiry |
KO19146 | C18orf54 Knockout cell line (A549) | Human | C18orf54 | 1:3~1:4 | Negative | Online Inquiry |
C18orf54 Gene Knockout Cell Lines are specifically engineered cellular systems that facilitate the investigation of the functions of the C18orf54 gene within a controlled laboratory environment. C18orf54, also known as chromosome 18 open reading frame 54, is a gene implicated in various biological processes and associated with certain pathologies. The knockout cell lines are generated through advanced gene-editing technologies, such as CRISPR/Cas9, which effectively disrupt the expression of the C18orf54 gene, thereby allowing researchers to assess the subsequent cellular phenotypes.
The primary mechanism of action involves the targeted deletion or modification of C18orf54, leading to a loss of its associated protein products. Researchers can observe downstream effects on cellular pathways, gene expression profiles, and phenotypic changes, providing insights into the physiological roles of C18orf54 in health and disease contexts. This is invaluable in deciphering its relevance in cancer biology, metabolic disorders, and developmental processes.
In a research or clinical setting, these knockout cell lines serve as a critical tool for elucidating gene function, validating drug targets, and exploring the mechanisms underlying various diseases. They are particularly significant in the field of pharmacogenomics, where understanding gene variants can lead to more personalized therapeutic strategies.
The advantages of utilizing C18orf54 Gene Knockout Cell Lines over alternative methods, such as transient transfection or RNA interference, lie in their stability and reproducibility. The knockout model provides a permanent alteration of the gene, allowing for long-term studies that consistently exhibit the effects of C18orf54 loss. Additionally, these cell lines can be utilized in high-throughput screening assays, making them suitable for extensive drug discovery efforts.
For researchers and clinicians, the implementation of C18orf54 Gene Knockout Cell Lines in their work can significantly enhance the understanding of genetic contributions to various diseases and aid in the development of novel therapeutic solutions. By collaborating with top-tier laboratories and utilizing cutting-edge techniques, our company ensures that these cell lines are rigorously validated and tailored to meet the specific needs of our users, underscoring our commitment to advancing biomolecular research and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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