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BSG Knockout Cell Lines

Gene: BSG

Official Full Name: basigin (Ok blood group)provided by HGNC

Gene Summary: The protein encoded by this gene, basigin, is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. Basigin is also a member of the immunoglobulin superfamily, ubiquitously expressed in various tissues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09985 BSG Knockout cell line (HeLa) Human BSG 1:3~1:6 Negative Online Inquiry
KO09986 BSG Knockout cell line (HCT 116) Human BSG 1:2~1:4 Negative Online Inquiry
KO09987 BSG Knockout cell line (HEK293) Human BSG 1:3~1:6 Negative Online Inquiry
KO09988 BSG Knockout cell line (A549) Human BSG 1:3~1:4 Negative Online Inquiry

Background

BSG Gene Knockout Cell Lines are specialized cellular models that have undergone precise genetic modifications to disable the expression of the BSG gene, which encodes the Basigin protein. This protein plays a crucial role in various biological processes, including cellular adhesion, signal transduction, and in the proliferation and differentiation of various cell types. By utilizing advanced CRISPR-Cas9 technology, these cell lines exhibit a complete knockout of the BSG gene, providing a powerful tool for researchers to study the gene’s functional roles and its implications in health and disease.

The primary function of BSG Gene Knockout Cell Lines is to facilitate the exploration of pathways mediated by the Basigin protein, which has been linked to conditions such as cancer, neuroinflammation, and infectious diseases. The absence of this gene allows for the analysis of phenotypic changes, cell behavior, and molecular interactions in a controlled environment, giving researchers insights into how manipulating BSG-related pathways might influence therapeutic outcomes.

These cell lines serve a critical function in scientific research and clinical settings, particularly in drug development, functional genomics, and cancer biology. The ability to use these models to elucidate the effects of BSG on other biological processes underscores their significance in developing novel therapeutic strategies and understanding disease mechanisms.

What sets BSG Gene Knockout Cell Lines apart from other genetic models is their high specificity and reliability, which inherently reduces off-target effects and experimental variability. Unlike conventional knockout methods, our cell lines exhibit a validated and stable knockout efficiency, enabling reproducible and consistent experimental results. This reliability enhances the credibility of research findings and contributes to the advancement of scientific knowledge.

For researchers and clinicians alike, these cell lines offer unparalleled value by allowing investigations that might lead to breakthroughs in understanding complex diseases and informing therapeutic innovations. Our commitment to quality and scientific excellence is reflected in our stringent production protocols and comprehensive support for our customers, ensuring they can leverage these advanced tools effectively in their research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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