Gene: BRWD3
Official Full Name: bromodomain and WD repeat domain containing 3provided by HGNC
Gene Summary: The protein encoded by this gene contains a bromodomain and several WD repeats. It is thought to have a chromatin-modifying function, and may thus play a role in transcription. Mutations in this gene are associated with a spectrum of cognitive disabilities and X-linked macrocephaly. This gene is also associated with translocations in patients with B-cell chronic lymphocytic leukemia. [provided by RefSeq, Jul 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07303 | BRWD3 Knockout cell line (HeLa) | Human | BRWD3 | 1:3~1:6 | Negative | Online Inquiry |
KO07304 | BRWD3 Knockout cell line (HCT 116) | Human | BRWD3 | 1:2~1:4 | Negative | Online Inquiry |
KO07305 | BRWD3 Knockout cell line (HEK293) | Human | BRWD3 | 1:3~1:6 | Negative | Online Inquiry |
KO07306 | BRWD3 Knockout cell line (A549) | Human | BRWD3 | 1:3~1:4 | Negative | Online Inquiry |
BRWD3 Gene Knockout Cell Lines are specialized cell lines engineered to have a targeted deletion of the BRWD3 gene, which encodes a chromatin-associated protein involved in transcriptional regulation and chromatin remodeling. These knockout models serve as an invaluable tool to study the gene's role in various biological processes, including cell proliferation, differentiation, and response to external stimuli. By eliminating the BRWD3 gene, researchers can gain insights into its pathway and functional contributions in cellular contexts, particularly those related to development and disease.
This product operates on the principle of gene editing through CRISPR/Cas9 technology, which allows for precise and efficient modifications of the genome. By carefully designing guide RNAs specific to the BRWD3 gene, researchers can induce double-strand breaks, leading to errors in repair that result in gene knockout. The resulting cell lines not only facilitate the study of BRWD3 function but also serve as models for investigating related pathologies, including cancer and metabolic disorders, given the gene's significant implication in gene expression regulation.
The scientific importance of BRWD3 Gene Knockout Cell Lines extends to their utility in drug discovery and translational research. In clinical settings, they can be employed for screening potential therapeutic agents or understanding mechanisms of drug resistance associated with BRWD3 dysregulation. These models can also inform the development of targeted therapies, making them invaluable to researchers and clinicians alike.
What sets these cell lines apart from conventional models is their specificity and the ease of use in various experimental setups. They provide researchers with a reliable and reproducible platform to analyze gene function without the confounding effects of heterogeneity present in other models. Furthermore, the ability to utilize these knockout cell lines alongside wild-type counterparts allows for comparative studies that enhance experimental rigor.
Investing in BRWD3 Gene Knockout Cell Lines ultimately empowers researchers and clinicians to uncover the intricate roles of the BRWD3 gene and its associated pathways, promoting advancements in genetics, molecular biology, and therapeutic development. Our company has extensive experience in producing genomic tools with high precision and reliability, assuring customers of the quality and effectiveness of our biological product offerings.
Please note that all services are for research use only. Not intended for any clinical use.
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