Gene: BMP6
Official Full Name: bone morphogenetic protein 6provided by HGNC
Gene Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11581 | BMP6 Knockout cell line (HeLa) | Human | BMP6 | 1:3~1:6 | Negative | Online Inquiry |
KO11582 | BMP6 Knockout cell line (HCT 116) | Human | BMP6 | 1:2~1:4 | Negative | Online Inquiry |
KO11583 | BMP6 Knockout cell line (HEK293) | Human | BMP6 | 1:3~1:6 | Negative | Online Inquiry |
KO11584 | BMP6 Knockout cell line (A549) | Human | BMP6 | 1:3~1:4 | Negative | Online Inquiry |
BMP6 Gene Knockout Cell Lines are engineered cellular models that have been specifically designed to lack the Bone Morphogenetic Protein 6 (BMP6) gene. This gene is known for its critical role in various biological processes, including bone formation, cellular growth regulation, and tissue differentiation. By disrupting the functionality of BMP6, these knockout cell lines serve as vital tools for researchers aiming to elucidate the broader implications of BMP signaling pathways in development and disease.
The key functions of BMP6 involve the modulation of osteoblast differentiation and proliferation, as well as its influence on the metabolic processes within various tissues. These knockout cell lines enable scientists to investigate the precise role of BMP6 in osteogenesis, pathology of bone-related diseases, and potential therapeutic targets. By employing techniques such as CRISPR/Cas9 gene editing, the knockout model allows for controlled studies of BMP signaling, giving insights into its mechanistic pathways and downstream effects.
From a scientific perspective, BMP6 Gene Knockout Cell Lines are invaluable in both basic and applied research settings. They provide a unique opportunity to study the functional consequences of BMP6 deficiency, facilitating investigations in areas such as osteoporosis, cancer biology, and regenerative medicine. Furthermore, these cell lines can serve as platforms for drug discovery, where novel compounds targeting BMP pathways may be screened and validated.
Compared to traditional wild-type cell lines, the BMP6 knockout variants yield more robust and specific data regarding BMP6 function, which enhances the reliability of research outcomes. Researchers benefit from the specificity of these models, reducing confounding factors that may arise from the presence of a functional BMP6 gene. This specificity is crucial for developing targeted therapies that could address unmet clinical needs.
For researchers and clinicians alike, the BMP6 Gene Knockout Cell Lines are an essential tool that streamlines experimentation and accelerates discovery. Our company specializes in providing high-quality, validated biological products, ensuring users have the reliable resources necessary for cutting-edge research. By integrating expertise in molecular biology and cell engineering, we deliver state-of-the-art models that empower the scientific community to further their understanding of complex biological systems.
Please note that all services are for research use only. Not intended for any clinical use.
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