Gene: BLTP2
Official Full Name: bridge-like lipid transfer protein family member 2provided by HGNC
Gene Summary: This gene was initially characterized in human as having high expression levels in breast carcinomas and breast cancer cell lines. This gene also has increased expression in prostrate cancer cells relative to normal prostrate tissues. Expression of this gene is negatively regulated by direct binding of the microRNA miR-195 to its 3' UTR. miR-195 has been shown to modulate the invasiveness of prostrate cancer cells and xenograft metastases by downgrading expression of this gene. In mouse, the protein encoded by this gene was identified as an antigen on acute monocytic leukemia cells. In human, alternative splicing results in multiple transcript variants encoding distinct isoforms; some of these isoforms are predicted to contain an RNA pol II promoter FMP27 protein domain and a Golgi-body-localization APT1 domain. [provided by RefSeq, Apr 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO19418 | BLTP2 Knockout cell line (HeLa) | Human | BLTP2 | 1:3~1:6 | Negative | Online Inquiry |
KO19419 | BLTP2 Knockout cell line (HCT 116) | Human | BLTP2 | 1:2~1:4 | Negative | Online Inquiry |
KO19420 | BLTP2 Knockout cell line (HEK293) | Human | BLTP2 | 1:3~1:6 | Negative | Online Inquiry |
KO19421 | BLTP2 Knockout cell line (A549) | Human | BLTP2 | 1:3~1:4 | Negative | Online Inquiry |
BLTP2 Gene Knockout Cell Lines are specifically engineered cellular models that have undergone targeted genetic modification to disable the BLTP2 gene, a crucial player in various biochemical pathways associated with lipid metabolism and cellular signaling. These knockout models provide researchers with invaluable tools to study the gene's function, elucidate its biological roles, and assess the consequences of its absence on cellular processes.
The primary mechanism by which BLTP2 knockout occurs involves the use of CRISPR-Cas9 technology, a revolutionary gene-editing tool that allows for precise modifications at the DNA level. By creating a double-strand break at the BLTP2 locus and facilitating inaccurate repair, researchers have successfully generated lines devoid of functional BLTP2 protein, enabling the investigation of resultant phenotypic changes. This can lead to better understanding of the molecular underpinnings of metabolic disorders, cancer biology, and other pathologies linked to lipid dynamics.
The scientific significance of BLTP2 Gene Knockout Cell Lines is evident in both basic research and clinical applications. They are indispensable for researchers aiming to unravel the complexities of lipid metabolism and its correlation with diseases such as cardiovascular disease, obesity, and diabetes. Furthermore, these cell lines can serve as responsive models for drug screening, toxicity assessments, and the development of therapeutic interventions targeting lipid regulation.
What sets our BLTP2 Gene Knockout Cell Lines apart from alternatives is their unparalleled reliability and reproducibility, achieved through rigorous validation processes. These cell lines are extensively characterized to ensure consistent performance across multiple experiments, leading to more reliable data and conclusions. Additionally, our commitment to providing high-quality genomic resources enables researchers to transition from foundational understanding to practical applications efficiently.
In summary, the BLTP2 Gene Knockout Cell Lines represent a critical advancement in the field of genetic research, empowering scientists to explore novel avenues in disease modeling and therapeutic development. Backed by our company’s expertise in genetic engineering and a dedication to innovation, we offer unparalleled support to researchers and clinicians in their quest to unravel complex biological questions.
Please note that all services are for research use only. Not intended for any clinical use.
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