Gene: BLMH
Official Full Name: bleomycin hydrolaseprovided by HGNC
Gene Summary: Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05508 | BLMH Knockout cell line (HeLa) | Human | BLMH | 1:3~1:6 | Negative | Online Inquiry |
KO05509 | BLMH Knockout cell line (HCT 116) | Human | BLMH | 1:2~1:4 | Negative | Online Inquiry |
KO05510 | BLMH Knockout cell line (HEK293) | Human | BLMH | 1:3~1:6 | Negative | Online Inquiry |
KO05511 | BLMH Knockout cell line (A549) | Human | BLMH | 1:3~1:4 | Negative | Online Inquiry |
BLMH Gene Knockout Cell Lines are sophisticated biological tools engineered to facilitate the study of BLMH gene function and its implications in various physiological processes and diseases. These cell lines have been created using CRISPR-Cas9 technology, enabling precise, targeted disruption of the BLMH gene, leading to a complete loss of its function. The knockout of this specific gene provides researchers with a powerful platform to investigate the underlying mechanisms of disease pathways and to uncover novel therapeutic targets.
The primary function of BLMH gene knockout is to allow for the elucidation of phenotypic changes resulting from the absence of this gene. By analyzing these modifications, such as alterations in cell proliferation, migration, or responses to specific stimuli, researchers can gain critical insights into the biological roles of the BLMH gene. Furthermore, these cell lines can be utilized to study gene interactions, signaling pathways, and metabolic processes, offering unprecedented depth in genomic analysis.
In the scientific community, the ability to develop knockout cell lines has significant implications, particularly in cancer research, pharmacology, and regenerative medicine. The application of BLMH gene knockout cell lines in high-throughput screening for drug discovery is invaluable, as it allows scientists to identify compounds that can modulate the gene's activity effectively. Additionally, the utilization of these cell lines in preclinical models can further bridge the gap between laboratory research and clinical applications.
One of the standout advantages of our BLMH gene knockout cell lines is their genetic stability and reproducibility, which are critical for consistent experimental outcomes. Unlike alternative methods that may yield variable results or off-target edits, the CRISPR-Cas9 approach employed ensures a high degree of precision, thus enhancing the reliability of experimental findings. Additionally, our product is backed by extensive validation, including genomic sequencing and functional assays, to confirm knockout efficacy.
For researchers and clinicians alike, the value of BLMH Gene Knockout Cell Lines lies in their potential to accelerate discovery and innovation in genomic research and therapeutics. Their contribution to the understanding of genetic mechanisms and disease pathology makes them an essential asset in any molecular biology laboratory.
Our expertise in gene editing and cellular models positions us as a leader in the field, and we are committed to providing high-quality biological products that empower scientific advancement and foster research breakthroughs.
Please note that all services are for research use only. Not intended for any clinical use.
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