Gene: BICD1
Official Full Name: BICD cargo adaptor 1provided by HGNC
Gene Summary: This gene encodes an adaptor protein that belongs to the bicaudal D family of dynein cargo adaptors. The encoded protein acts as an intracellular cargo transport cofactor that regulates the microtubule-based loading of cargo onto the dynein motor complex. It also controls dynein motor activity and coordination. It has a domain architecture consisting of coiled-coil domains at the N- and C-termini that are highly conserved in other family members. Naturally occurring mutations in this gene are associated with short telomere length and emphysema. [provided by RefSeq, Aug 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38815 | BICD1 Knockout cell line (HeLa) | Human | BICD1 | 1:3~1:6 | Negative | Online Inquiry |
KO38816 | BICD1 Knockout cell line (HCT 116) | Human | BICD1 | 1:2~1:4 | Negative | Online Inquiry |
KO38817 | BICD1 Knockout cell line (HEK293) | Human | BICD1 | 1:3~1:6 | Negative | Online Inquiry |
KO38818 | BICD1 Knockout cell line (A549) | Human | BICD1 | 1:3~1:4 | Negative | Online Inquiry |
BICD1 Gene Knockout Cell Lines are genetically engineered cell lines that have been specifically modified to disrupt the BICD1 gene, which plays a critical role in intracellular transport and cellular organization. These cell lines serve as valuable tools for understanding the biological functions of BICD1 by allowing researchers to study its effects on cellular processes such as vesicle trafficking, mitochondrial distribution, and cell division.
The mechanism of action underlying these cell lines involves the complete knockout of the BICD1 gene, leading to the resultant loss of function of the BICD1 protein. This disruption provides insights into the phenotypic consequences of BICD1 deficiency and its downstream effects on cellular homeostasis. By utilizing these knockout cell lines, researchers can investigate the altered pathways and potential compensatory mechanisms activated in the absence of BICD1, enhancing our understanding of its role in health and disease.
The scientific importance of BICD1 Gene Knockout Cell Lines extends to various research and clinical applications, especially in cancer biology and neurodegenerative diseases where BICD1 has been implicated. By facilitating the study of gene function and the elucidation of molecular pathways, these cell lines are instrumental in advancing drug discovery and therapeutic strategies.
Compared to alternative methods like RNA interference or CRISPR/Cas9 technologies, BICD1 Gene Knockout Cell Lines provide a stable and consistent platform for the analysis of gene function without the transient effects associated with temporary knockdown approaches. This stability enhances reproducibility and reliability in experimental designs.
For researchers and clinicians, these knockouts offer a powerful advantage in delineating the physiological relevance of BICD1, fostering innovative research and potential new therapeutic approaches. Our company brings extensive expertise in developing high-quality, reliable genetic tools, ensuring that researchers have access to resources that are crucial for achieving their scientific goals and driving breakthroughs in biomedical research.
Please note that all services are for research use only. Not intended for any clinical use.
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