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BFSP1 Knockout Cell Lines

Gene: BFSP1

Official Full Name: beaded filament structural protein 1provided by HGNC

Gene Summary: This gene encodes a lens-specific intermediate filament-like protein named filensin. The encoded protein is expressed in lens fiber cells after differentiation has begun. This protein functions as a component of the beaded filament which is a cytoskeletal structure found in lens fiber cells. Mutations in this gene are the cause of autosomal recessive cortical juvenile-onset cataract. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38819 BFSP1 Knockout cell line (HeLa) Human BFSP1 1:3~1:6 Negative Online Inquiry
KO38820 BFSP1 Knockout cell line (HCT 116) Human BFSP1 1:2~1:4 Negative Online Inquiry
KO38821 BFSP1 Knockout cell line (HEK293) Human BFSP1 1:3~1:6 Negative Online Inquiry
KO38822 BFSP1 Knockout cell line (A549) Human BFSP1 1:3~1:4 Negative Online Inquiry

Background

BFSP1 Gene Knockout Cell Lines are specialized biological models created to facilitate the study of the BFSP1 gene, which encodes a key protein involved in the structural integrity and function of cellular components, particularly within lens fibers in the eye. By utilizing CRISPR-Cas9 gene editing technology, these cell lines have been genetically modified to completely eliminate BFSP1 expression, allowing researchers to investigate the downstream effects of its absence.

The primary function of these knockout cell lines is to serve as a vital tool for understanding the role of BFSP1 in cellular processes such as differentiation, proliferation, and apoptosis. Researchers can elucidate the pathways affected by the lack of BFSP1, potentially linking these to various ocular diseases, particularly cataracts and other lens-related disorders. The unobstructed examination of the BFSP1 gene's role in cellular behavior makes these cell lines an essential asset in both basic research and translational studies.

From a scientific perspective, the BFSP1 Gene Knockout Cell Lines are indispensable in exploring not only the cellular mechanisms but also possible therapeutic targets for eye disease. In clinical settings, they provide a platform for evaluating drug responses and genetic interactions that may arise in BFSP1-deficient cells, paving the way for innovative interventions.

Compared to traditional cell lines, our BFSP1 Gene Knockout cell lines offer specificity and precision that are crucial for obtaining reliable results. The complete knockout of BFSP1 ensures that any observed phenotypic or functional changes can be directly attributed to the absence of the gene, minimizing confounding variables that might arise with partial knockdowns or overexpression systems.

For researchers and clinicians focused on eye health and genetic disorders, BFSP1 Gene Knockout Cell Lines represent a unique and powerful approach to unraveling complex biological questions and developing targeted therapies. Their ability to model human disease at the cellular level adds significant value to research initiatives.

With years of experience in producing high-quality genetic models, our company stands at the forefront of biotechnology innovation, dedicated to equipping the scientific community with tools that accelerate discovery and enhance human health.

Please note that all services are for research use only. Not intended for any clinical use.

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