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BET1L Knockout Cell Lines

Gene: BET1L

Official Full Name: Bet1 golgi vesicular membrane trafficking protein likeprovided by HGNC

Gene Summary: Enables SNAP receptor activity. Involved in regulation of retrograde vesicle-mediated transport, Golgi to ER and retrograde transport, endosome to Golgi. Located in Golgi apparatus and endosome. Implicated in uterine fibroid. Biomarker of endometrial adenocarcinoma. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22770 BET1L Knockout cell line (HeLa) Human BET1L 1:3~1:6 Negative Online Inquiry
KO22771 BET1L Knockout cell line (HCT 116) Human BET1L 1:2~1:4 Negative Online Inquiry
KO22772 BET1L Knockout cell line (HEK293) Human BET1L 1:3~1:6 Negative Online Inquiry
KO22773 BET1L Knockout cell line (A549) Human BET1L 1:3~1:4 Negative Online Inquiry

Background

BET1L Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the functional study of the BET1L gene, which encodes a critical component involved in various cellular processes, including vesicle transport and membrane trafficking. These knockout cell lines are created using CRISPR/Cas9 gene editing technology to precisely eliminate the BET1L gene, allowing researchers to investigate its cellular roles and interplay with other key biological pathways.

The primary mechanism of the BET1L knockout cell lines revolves around the absence of the BET1L protein, leading to alterations in vesicular transport dynamics, which can significantly affect processes like endocytosis and exocytosis. By using these lines, scientists can elucidate the pathological implications of BET1L dysfunction in diseases such as neurodegenerative disorders and cancer, thereby enhancing the understanding of disease mechanisms.

In research and clinical contexts, these cell lines serve as valuable tools for screening potential therapeutic compounds and assessing drug efficacy related to vesicular transport dysregulation. Their use can accelerate the discovery of novel treatments and contribute to the ongoing exploration of gene function in health and disease.

The advantages of utilizing BET1L Gene Knockout Cell Lines over traditional models lie in their high specificity and adaptability. These lines provide a more precise understanding of gene function compared to unspecific knockdown approaches, such as RNA interference, which often lead to off-target effects.

Researchers and clinicians stand to gain significantly from engaging with these knockout cell lines due to their enhanced reliability and reproducibility, ultimately accelerating experimental timelines and contributing to more robust data outcomes. Our company, a leader in the development of innovative biological models, is committed to providing researchers with state-of-the-art tools such as the BET1L Gene Knockout Cell Lines, enabling breakthroughs in scientific research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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