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BCKDK Knockout Cell Lines

Gene: BCKDK

Official Full Name: branched chain keto acid dehydrogenase kinaseprovided by HGNC

Gene Summary: The branched-chain alpha-ketoacid dehydrogenase complex (BCKD) is an important regulator of the valine, leucine, and isoleucine catabolic pathways. The protein encoded by this gene is found in the mitochondrion, where it phosphorylates and inactivates BCKD. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09300 BCKDK Knockout cell line (HeLa) Human BCKDK 1:3~1:6 Negative Online Inquiry
KO09301 BCKDK Knockout cell line (HCT 116) Human BCKDK 1:2~1:4 Negative Online Inquiry
KO09302 BCKDK Knockout cell line (HEK293) Human BCKDK 1:3~1:6 Negative Online Inquiry
KO09303 BCKDK Knockout cell line (A549) Human BCKDK 1:3~1:4 Negative Online Inquiry

Background

BCKDK Gene Knockout Cell Lines are genetically engineered cell models specifically designed to facilitate the study of the BCKDK gene and its associated biological pathways. This innovative tool allows researchers to generate insights into branched-chain amino acid metabolism, as BCKDK is a regulator that impacts energy homeostasis and contributes to various metabolic disorders. By disabling the BCKDK gene, these cell lines create a controlled environment to analyze alterations in metabolic processes and cellular responses, providing a robust framework for understanding the implications of BCKDK deficiency.

The primary function of BCKDK Gene Knockout Cell Lines is to serve as an in vitro model for exploring the role of BCKDK within the context of different cellular conditions. The knockout mechanism provides a unique opportunity to observe changes in metabolite levels, signaling pathways, and overall cellular behavior, which are critical for elucidating the gene's function and therapeutic potential. As researchers study these cell lines, they can assess the implications of BCKDK's regulatory functions in disease states, particularly those linked to metabolism, such as obesity, diabetes, and some neurodegenerative conditions.

The scientific importance of these knockout cell lines lies in their ability to advance research on metabolic disorders, offering a powerful platform for drug discovery and development. By utilizing these models, researchers can identify potential therapeutic targets and evaluate drug efficacy and safety in a precise manner. Furthermore, these cell lines enable high-throughput screening, thereby accelerating the pace of metabolic research.

One of the significant advantages of BCKDK Gene Knockout Cell Lines over traditional cell models is their specificity and reliability in studying the BCKDK gene’s effects. Unlike conventional methods that may yield mixed or ambiguous results, these knockout models promote high fidelity in experimentation, allowing for reproducible and conclusive outcomes. Additionally, the streamlined workflow supports scalability and adaptability in various laboratory settings.

For researchers and clinicians focused on metabolites and related disorders, BCKDK Gene Knockout Cell Lines present an unparalleled opportunity to investigate fundamental biological questions and translational applications. Their unique characteristics empower scientists to push the boundaries of knowledge in metabolic health and facilitate the development of cutting-edge therapies.

Our company prides itself on its deep expertise in creating innovative biological products tailored to meet the evolving needs of the research community. With a commitment to quality and reliability, we strive to enhance the scientific landscape through advanced tools like BCKDK Gene Knockout Cell Lines, paving the way for future discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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