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BBS7 Knockout Cell Lines

Gene: BBS7

Official Full Name: Bardet-Biedl syndrome 7provided by HGNC

Gene Summary: This gene encodes one of eight proteins that form the BBSome complex containing BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9 and BBIP10. The BBSome complex is believed to recruit Rab8(GTP) to the primary cilium and promote ciliogenesis. The BBSome complex assembly is mediated by a complex composed of three chaperonin-like BBS proteins (BBS6, BBS10, and BBS12) and CCT/TRiC family chaperonins. Mutations in this gene are implicated in Bardet-Biedl syndrome, a genetic disorder whose symptoms include obesity, retinal degeneration, polydactyly and nephropathy; however, mutations in this gene and the BBS8 gene are thought to play a minor role and mutations in chaperonin-like BBS genes are found to be a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population. Two transcript variants encoding distinct isoforms have been identified for this gene.[provided by RefSeq, Oct 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19475 BBS7 Knockout cell line (HeLa) Human BBS7 1:3~1:6 Negative Online Inquiry
KO19476 BBS7 Knockout cell line (HCT 116) Human BBS7 1:2~1:4 Negative Online Inquiry
KO19477 BBS7 Knockout cell line (HEK293) Human BBS7 1:3~1:6 Negative Online Inquiry
KO19478 BBS7 Knockout cell line (A549) Human BBS7 1:3~1:4 Negative Online Inquiry

Background

BBS7 Gene Knockout Cell Lines are genetically engineered cell lines specifically modified to disrupt the function of the BBS7 gene, which is linked to Bardet-Biedl Syndrome (BBS) and other critical biological processes. These knockout cell lines serve as invaluable tools for researchers aiming to elucidate the role of BBS7 in cellular mechanisms, signaling pathways, and disease etiology. The knockout mechanism involves CRISPR-Cas9 technology, allowing for precise editing of the target gene, resulting in a loss-of-function scenario that enables the investigation of phenotypic consequences.

The importance of using BBS7 Gene Knockout Cell Lines in research cannot be overstated. They facilitate the study of BBS-related pathophysiology, including defects in cilia formation and function that are integral to various cellular processes. These models can be utilized in pharmacological studies to assess potential therapeutic interventions or in genetic research to explore the interplay between BBS7 and other genes implicated in ciliary diseases.

One of the key advantages of BBS7 Gene Knockout Cell Lines is their specificity and reproducibility, allowing for consistent results that are critical for experimental validation. Unlike alternative models that may possess off-target effects or genetic variability, these lines offer a controlled environment that helps researchers achieve clearer insights into the gene's biological role. Furthermore, the ability to assess changes in cell behavior, signaling molecules, and gene expression makes them a versatile asset across different areas of biological research.

For researchers and clinicians alike, these cell lines provide a robust platform for advancing understanding of Bardet-Biedl Syndrome and other related ciliary disorders. Their deployment can lead to the discovery of novel therapeutic targets and contribute to the development of effective treatment strategies. At [Your Company Name], we pride ourselves on our commitment to providing high-quality, state-of-the-art biological products backed by extensive expertise in genetic engineering and cell biology, empowering scientists with the tools they need to drive groundbreaking discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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