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B3GNT7 Knockout Cell Lines

Gene: B3GNT7

Official Full Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7provided by HGNC

Gene Summary: Enables acetylglucosaminyltransferase activity. Involved in keratan sulfate biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22411 B3GNT7 Knockout cell line (HCT 116) Human B3GNT7 1:2~1:4 Negative Online Inquiry
KO22412 B3GNT7 Knockout cell line (A549) Human B3GNT7 1:3~1:4 Negative Online Inquiry

Background

B3GNT7 Gene Knockout Cell Lines are sophisticated biological tools designed to facilitate the study of the B3GNT7 gene and its associated pathways by eliminating its expression in cellular contexts. This product is generated through advanced CRISPR-Cas9 technology, ensuring precise editing to introduce targeted deletions in the B3GNT7 gene. These cell lines serve as essential resources for researchers aiming to dissect the functional roles of B3GNT7 in glycosylation processes, which are critical for cell-cell interactions and signaling pathways.

The primary mechanism of action involves the disruption of the B3GNT7 gene, which encodes for an enzyme involved in the synthesis of specific glycan structures. By knocking out this gene, these cell lines enable scientists to observe the resultant phenotypic changes and elucidate the gene's contributions to various biological functions. This provides valuable insights into the role of glycosylation in biological processes such as immune response, cancer progression, and cellular adhesion mechanisms.

The scientific significance of B3GNT7 Gene Knockout Cell Lines extends to their applications in both research and clinical settings. They serve as pivotal models for cancer research, therapeutic development, and the study of genetic diseases related to glycosylation defects. Additionally, these cell lines can aid in the identification of novel drug targets and biomarkers, thereby accelerating translational research.

In comparison to alternatives such as RNA interference or the use of wild-type cells, B3GNT7 Gene Knockout Cell Lines offer the distinct advantage of complete gene ablation. This allows for clearer interpretation of results without the complications that may arise from partial gene function retention or off-target effects.

For researchers and clinicians, the value of these knockout cell lines lies in their ability to provide reliable and reproducible models for studying the biological implications of B3GNT7 deficiency. As a product from a leading biotechnology firm specializing in gene editing technologies, we are committed to supporting your research with high-quality biological products that pave the way for breakthroughs in the understanding of cellular mechanisms.

Please note that all services are for research use only. Not intended for any clinical use.

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