Gene: AUP1
Official Full Name: AUP1 lipid droplet regulating VLDL assembly factorprovided by HGNC
Gene Summary: The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38866 | AUP1 Knockout cell line (HeLa) | Human | AUP1 | 1:3~1:6 | Negative | Online Inquiry |
KO38867 | AUP1 Knockout cell line (HCT 116) | Human | AUP1 | 1:2~1:4 | Negative | Online Inquiry |
KO38868 | AUP1 Knockout cell line (HEK293) | Human | AUP1 | 1:3~1:6 | Negative | Online Inquiry |
KO38869 | AUP1 Knockout cell line (A549) | Human | AUP1 | 1:3~1:4 | Negative | Online Inquiry |
AUP1 Gene Knockout Cell Lines are engineered cellular models designed to elucidate the role of the AUP1 gene in various biological processes. AUP1 (asparagine–serine–threonine protein 1), a gene implicated in diverse cellular functions including apoptosis and cell signaling, is targeted for knockout using CRISPR-Cas9 technology. This precise gene-editing technique enables the generation of cell lines lacking functional AUP1 protein, allowing researchers to investigate the gene’s contributions to vital cellular mechanisms.
The key function of AUP1 Gene Knockout Cell Lines lies in their ability to facilitate studies on gene expression, protein interactions, and metabolic pathways. By comparing the knockout cell lines to their wild-type counterparts, scientists can elucidate the specific pathways influenced by AUP1, thus gaining insights into potential dysregulations in disease states, including cancer and metabolic disorders. Additionally, these cell lines serve as valuable tools for drug screening, enabling the identification of pharmacological agents that selectively target AUP1-related pathways.
The scientific importance of AUP1 Gene Knockout Cell Lines extends into both research and clinical applications. They provide a robust platform for functional genomics studies, allowing for the identification of therapeutic targets and the understanding of disease mechanisms at a molecular level. As validation tools for compound efficacy and safety, they play a crucial role in translational medicine.
What differentiates AUP1 Gene Knockout Cell Lines from alternative models is their specificity and reliability. The precise CRISPR-Cas9 construction ensures a complete loss of the target gene, delivering reproducible and consistent results across experiments. Furthermore, these cell lines are fully validated, allowing researchers to save time and resources associated with characterizing gene knockout efficiency and functionality.
For researchers and clinicians, the use of AUP1 Gene Knockout Cell Lines provides a significant advantage in dissecting complex biological systems and paves the way for novel therapeutic strategies. Their potential for advancing our understanding of gene function and disease pathology makes them an indispensable asset in modern biological research and drug development.
At our company, we pride ourselves on our expertise in producing high-quality biological products that empower scientists in their quest for knowledge and innovation. Our commitment to quality and research excellence ensures that our AUP1 Gene Knockout Cell Lines are not only cutting-edge but also fully supportive of your scientific endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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