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AUH Knockout Cell Lines

Gene: AUH

Official Full Name: AU RNA binding methylglutaconyl-CoA hydrataseprovided by HGNC

Gene Summary: This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03176 AUH Knockout cell line (HeLa) Human AUH 1:3~1:6 Negative Online Inquiry
KO03177 AUH Knockout cell line (HCT 116) Human AUH 1:2~1:4 Negative Online Inquiry
KO03178 AUH Knockout cell line (HEK293) Human AUH 1:3~1:6 Negative Online Inquiry
KO03179 AUH Knockout cell line (A549) Human AUH 1:3~1:4 Negative Online Inquiry

Background

AUH Gene Knockout Cell Lines are precisely engineered cellular models designed to study the effects of the loss of the AUH (a favored gene associated with various metabolic pathways) function. These cell lines have undergone a rigorous process of gene editing, typically accomplished using CRISPR-Cas9 technology, which allows for targeted disruption of the AUH gene, enabling researchers to observe phenotypic changes and elucidate the role of AUH in cellular function and disease.

The key mechanism of action behind these knockout cell lines lies in their capability to mimic gene deletions that occur in various pathological conditions, offering insights into the gene's biological role and implications. By disrupting the AUH gene, the cell lines provide a relevant platform for studying metabolic dysfunctions and their contribution to cellular processes such as apoptosis, proliferation, and stress response mechanisms.

In the realm of scientific research and clinical studies, AUH Gene Knockout Cell Lines hold significant importance. They serve as invaluable tools for investigating disease mechanisms, particularly in the context of cancer and metabolic disorders. Researchers can utilize these models to test therapeutic interventions, assess drug efficacy, and explore genetic interactions within metabolic pathways, thereby accelerating translational research efforts.

Compared to traditional cell lines, AUH Gene Knockout Cell Lines offer unique advantages, including a high degree of specificity and reproducibility. Unlike random mutagenesis approaches, CRISPR technology ensures that the gene knockout is precise, minimizing off-target effects and leading to more reliable results. This specificity is a pivotal aspect that enhances data integrity and makes these cell lines an essential asset in both academic and pharmaceutical research settings.

For researchers and clinicians, the value of AUH Gene Knockout Cell Lines lies in their potential to reveal new therapeutic targets and biomarkers associated with diseases linked to the AUH gene. By utilizing these models, scientists can overcome significant challenges in understanding complex biological pathways and contribute to the development of innovative therapeutic strategies.

Our company specializes in the production and optimization of biological products tailored to meet the precise needs of the scientific community. With a strong emphasis on quality, innovation, and customer support, we are committed to advancing research and helping you achieve your scientific goals with our cutting-edge offerings.

Please note that all services are for research use only. Not intended for any clinical use.

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