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ATP23 Knockout Cell Lines

Gene: ATP23

Official Full Name: ATP23 metallopeptidase and ATP synthase assembly factor homologprovided by HGNC

Gene Summary: The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00426 ATP23 Knockout cell line (HEK293) Human ATP23 1:3~1:6 Negative Online Inquiry
KO23477 ATP23 Knockout cell line (HeLa) Human ATP23 1:3~1:6 Negative Online Inquiry
KO23478 ATP23 Knockout cell line (HCT 116) Human ATP23 1:2~1:4 Negative Online Inquiry
KO23479 ATP23 Knockout cell line (A549) Human ATP23 1:3~1:4 Negative Online Inquiry

Background

ATP23 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to lack the ATP23 gene, a key player in mitochondrial function and cellular energy metabolism. These cell lines serve as vital tools for studying the biological implications of ATP23 deficiency and the role of mitochondrial dynamics in various physiological and pathological conditions.

The mechanism of action hinges on the targeted disruption of the ATP23 gene, achieved through advanced genome editing techniques such as CRISPR-Cas9. By knocking out this gene, researchers can observe how the absence of ATP23 affects mitochondrial biogenesis, oxidative phosphorylation, and ATP production. This provides critical insights into metabolic disorders, neurodegenerative diseases, and cancer, where mitochondrial function often plays a pivotal role.

The scientific importance of ATP23 Gene Knockout Cell Lines extends to both basic research and clinical applications. In research settings, these cell lines enable scientists to explore the mechanistic pathways associated with ATP23, facilitating the identification of potential therapeutic targets. Clinically, understanding ATP23-dependent pathways may lead to novel interventions in diseases characterized by mitochondrial dysfunction, including certain myopathies and metabolic syndromes.

What sets ATP23 Gene Knockout Cell Lines apart from alternative models is their precise genetic modification, ensuring high specificity and reproducibility in experiments. This rigor improves the reliability of experimental outcomes, thus reducing variability often encountered with traditional cell models.

Researchers and clinicians can greatly benefit from employing these cell lines in their studies, as they provide unparalleled insights into mitochondrial biology and disease mechanisms. By facilitating the development of targeted therapies and advancing our understanding of mitochondrial disorders, ATP23 Gene Knockout Cell Lines represent a significant advancement in biological research.

Our company prides itself on its expertise in providing high-quality, innovative genetic tools to the scientific community. Committed to advancing research, we ensure that our products, such as ATP23 Gene Knockout Cell Lines, are rigorously validated and tailored to meet the unique needs of our customers, driving discoveries in mitochondrial research and beyond.

Please note that all services are for research use only. Not intended for any clinical use.

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