Gene: ATOX1
Official Full Name: antioxidant 1 copper chaperoneprovided by HGNC
Gene Summary: This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05099 | ATOX1 Knockout cell line (HeLa) | Human | ATOX1 | 1:3~1:6 | Negative | Online Inquiry |
KO05100 | ATOX1 Knockout cell line (HCT 116) | Human | ATOX1 | 1:2~1:4 | Negative | Online Inquiry |
KO05101 | ATOX1 Knockout cell line (HEK293) | Human | ATOX1 | 1:3~1:6 | Negative | Online Inquiry |
KO05102 | ATOX1 Knockout cell line (A549) | Human | ATOX1 | 1:3~1:4 | Negative | Online Inquiry |
ATOX1 Gene Knockout Cell Lines are specialized cellular models designed to eliminate the expression of the ATOX1 gene, which encodes a copper chaperone critical for cellular copper homeostasis. By utilizing CRISPR-Cas9 technology, these cell lines enable precise gene editing, resulting in the complete ablation of ATOX1 functions. This knockout results in altered cellular behavior, providing a robust platform for studying the role of copper transport and its implications in various biological processes, including oxidative stress response and metal ion metabolism.
The primary function of these knockout cell lines is to facilitate research into the pathophysiological roles of ATOX1 in diseases such as cancer and neurodegenerative disorders. By eliminating ATOX1, researchers can observe the downstream effects on cell viability, proliferation, and apoptosis, thereby elucidating the gene's contribution to disease progression. Moreover, without the confounding influence of ATOX1, scientists can explore the impact of copper dysregulation on cellular pathways in a controlled environment.
In the realm of scientific research and clinical applications, ATOX1 Gene Knockout Cell Lines serve as a vital tool for researchers aiming to understand copper's role in health and disease. Their unique combination of targeted gene deletion and the ability to model specific pathologies positions them as an invaluable asset in elucidating the mechanisms behind copper-related disorders and testing potential therapeutic strategies.
What sets these cell lines apart from conventional knockout models is their high specificity and efficiency in gene editing. Compared to other available products, ATOX1 Gene Knockout Cell Lines provide a reliable option for in-depth functional studies, reducing noise from off-target effects that can arise in less precise methodologies.
The substantial groundwork in cellular genetics and the proven track record of our company's innovative solutions underscores our commitment to advancing research in the biological sciences. With our expertise in delivering high-quality biological products, researchers and clinicians can trust that ATOX1 Gene Knockout Cell Lines are a significant enhancement to their experimental toolkit, paving the way for groundbreaking discoveries in cellular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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