Gene: ATL3
Official Full Name: atlastin GTPase 3provided by HGNC
Gene Summary: This gene encodes a member of a family of dynamin-like, integral membrane GTPases. The encoded protein is required for the proper formation of the network of interconnected tubules of the endoplasmic reticulum. Mutations in this gene may be associated with hereditary sensory neuropathy type IF. Alternatively spliced transcript variants that encode distinct isoforms have been described. [provided by RefSeq, Feb 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28627 | ATL3 Knockout cell line (HeLa) | Human | ATL3 | 1:3~1:6 | Negative | Online Inquiry |
KO28628 | ATL3 Knockout cell line (HCT 116) | Human | ATL3 | 1:2~1:4 | Negative | Online Inquiry |
KO28629 | ATL3 Knockout cell line (HEK293) | Human | ATL3 | 1:3~1:6 | Negative | Online Inquiry |
KO28630 | ATL3 Knockout cell line (A549) | Human | ATL3 | 1:3~1:4 | Negative | Online Inquiry |
ATL3 Gene Knockout Cell Lines represent a groundbreaking advancement in the arena of genetic research and cellular biology. These specialized cell lines are genetically engineered to lack the ATL3 gene, which plays a critical role in the regulation of endoplasmic reticulum (ER) dynamics and mitochondrial function. By providing a precise model to study the functional consequences of ATL3 deficiency, these knockout cell lines enable researchers to explore the molecular pathways involved in a variety of diseases, including neurodegeneration and metabolic disorders.
The primary function of ATL3 knockout cell lines revolves around their utility in dissecting the roles of the ATL3 protein in cellular processes such as lipid metabolism, cell signaling, and apoptosis. By employing advanced gene editing techniques, these cell lines allow for the observation of phenotypic and molecular changes in response to ATL3 loss, providing insights into how this protein influences cellular homeostasis and its implications in disease pathology. This mechanistic understanding is pivotal for developing targeted therapeutic strategies.
In research and clinical settings, ATL3 Gene Knockout Cell Lines stand out for their ability to facilitate high-throughput screening of compounds aimed at modulating ATL3-related pathways. Their precision allows for reproducibility in experimental results, making them essential tools for drug discovery and mechanistic studies. Compared to traditional models, these knockout lines offer a significant advantage by allowing for a more targeted investigation of ATL3's functions without the confounding effects of gene redundancy.
For researchers and clinicians, the value of ATL3 Gene Knockout Cell Lines lies in their ability to deepen our understanding of disease mechanisms and enhance translational research efforts. The specificity of these cell lines can accelerate the discovery of novel therapeutic targets, making them crucial for advancing personalized medicine.
Equipped with expertise in genetic modifications and a commitment to quality, our company is dedicated to supporting researchers with premier biological products such as ATL3 Gene Knockout Cell Lines, empowering them to make significant strides in their studies.
Please note that all services are for research use only. Not intended for any clinical use.
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