Gene: ASAP1
Official Full Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 1provided by HGNC
Gene Summary: This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02359 | ASAP1 Knockout cell line (HeLa) | Human | ASAP1 | 1:3~1:6 | Negative | Online Inquiry |
KO02360 | ASAP1 Knockout cell line (HCT 116) | Human | ASAP1 | 1:2~1:4 | Negative | Online Inquiry |
KO02361 | ASAP1 Knockout cell line (HEK293) | Human | ASAP1 | 1:3~1:6 | Negative | Online Inquiry |
KO02362 | ASAP1 Knockout cell line (A549) | Human | ASAP1 | 1:3~1:4 | Negative | Online Inquiry |
ASAP1 Gene Knockout Cell Lines are specialized cellular models engineered to completely inactivate the ASAP1 gene, which encodes an adaptor protein involved in intracellular signaling pathways and cellular trafficking processes. By utilizing CRISPR/Cas9 technology for the precise editing of the genome, these cell lines provide a robust platform for studying the functional roles of ASAP1 in various biological contexts, including cancer progression, metastasis, and cellular response to stimuli.
The primary mechanism of action in ASAP1 knockout cell lines involves the complete loss of the protein's expression, which allows researchers to assess phenotypic changes and molecular interactions resulting from this genetic alteration. This cellular platform enables comprehensive investigations into the signaling pathways modulated by ASAP1, such as those linked to cytoskeletal dynamics and cell adhesion. These unique properties make the ASAP1 knockout cell lines invaluable in both basic and applied research, particularly in exploring therapeutic targets for diseases associated with aberrant ASAP1 activity.
One of the distinct advantages of using ASAP1 Gene Knockout Cell Lines is their specificity and reproducibility in experimental outcomes. Unlike traditional knockdown methods that only reduce gene expression temporarily, knockout techniques lead to permanent gene inactivation, ensuring that the observed effects are unequivocally linked to the loss of ASAP1 function. Furthermore, these cell lines provide a consistent and reliable tool for drug screening and biomarker discovery, making them a preferable choice for researchers aiming to translate findings into clinical applications.
For researchers and clinicians alike, the value of these cell lines is exponential, given their capacity to offer insights into the pathophysiology of diseases related to the ASAP1 gene. They present an opportunity to identify new therapeutic strategies and validate targets for drug development, ultimately contributing to advancements in personalized medicine.
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