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ASAH1 Knockout Cell Lines

Gene: ASAH1

Official Full Name: N-acylsphingosine amidohydrolase 1provided by HGNC

Gene Summary: This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene are associated with the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. [provided by RefSeq, Oct 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07642 ASAH1 Knockout cell line (HeLa) Human ASAH1 1:3~1:6 Negative Online Inquiry
KO07643 ASAH1 Knockout cell line (HCT 116) Human ASAH1 1:2~1:4 Negative Online Inquiry
KO07644 ASAH1 Knockout cell line (HEK293) Human ASAH1 1:3~1:6 Negative Online Inquiry
KO07645 ASAH1 Knockout cell line (A549) Human ASAH1 1:3~1:4 Negative Online Inquiry

Background

ASAH1 Gene Knockout Cell Lines are genetically engineered models that have been created to specifically eliminate the expression of the ASAH1 gene. This gene encodes the enzyme acid ceramidase, which is crucial for ceramide metabolism and lipid signaling pathways within cells. By knocking out ASAH1, these cell lines serve as valuable tools for studying the intricate biological functions of ceramide and its involvement in various physiological and pathological processes, such as apoptosis, neurodegeneration, and cancer progression.

The fundamental mechanism of ASAH1 Gene Knockout Cell Lines lies in their ability to facilitate the examination of cellular behavior in the absence of acid ceramidase, allowing researchers to investigate the resulting metabolic shifts and gene expression changes. These cell lines can be instrumental in elucidating the precise roles of ceramides as signaling molecules and their implications in disease mechanisms, ultimately aiding in the development of targeted therapies.

From a scientific perspective, the importance of ASAH1 Gene Knockout Cell Lines spans both research and clinical applications. They provide a controlled environment for drug testing and biomolecular studies, contributing to the identification of potential therapeutic targets and treatment strategies, particularly in cancers and neurodegenerative disorders where ceramide pathways are dysregulated.

One of the distinct advantages of using ASAH1 Gene Knockout Cell Lines is the specificity with which researchers can scrutinize the effects of ceramide modulation without the confounding influence of acid ceramidase. Unlike alternative models, these knockout cell lines offer an unparalleled depth of insight into ceramide biology, enhancing the robustness of experimental results and improving reproducibility across studies.

Given the increased focus on lipid metabolism in disease contexts, ASAH1 Gene Knockout Cell Lines represent a crucial resource for researchers and clinicians alike. Their ability to mimic disease-like conditions, combined with their accessibility and reliability, makes them indispensable for advancing the understanding of cellular mechanisms in various contexts.

Our company specializes in providing high-quality genetic models and innovative research solutions, underpinned by a commitment to scientific excellence and reliability. The ASAH1 Gene Knockout Cell Lines exemplify our dedication to supporting researchers in unraveling complex biological questions and contributing to transformative discoveries in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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