Home / ARHGEF9 Knockout Cell Lines

ARHGEF9 Knockout Cell Lines

Gene: ARHGEF9

Official Full Name: Cdc42 guanine nucleotide exchange factor 9provided by HGNC

Gene Summary: The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. This brain-specific protein also acts as an adaptor protein for the recruitment of gephyrin and together these proteins facilitate receceptor recruitement in GABAnergic and glycinergic synapses. Defects in this gene are the cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy, as well as several other types of cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29667 ARHGEF9 Knockout cell line (HeLa) Human ARHGEF9 1:3~1:6 Negative Online Inquiry
KO29668 ARHGEF9 Knockout cell line (HCT 116) Human ARHGEF9 1:2~1:4 Negative Online Inquiry
KO29669 ARHGEF9 Knockout cell line (HEK293) Human ARHGEF9 1:3~1:6 Negative Online Inquiry
KO29670 ARHGEF9 Knockout cell line (A549) Human ARHGEF9 1:3~1:4 Negative Online Inquiry

Background

ARHGEF9 Gene Knockout Cell Lines represent a pioneering set of biological tools that enable researchers to investigate the functional roles of the ARHGEF9 gene, known for its involvement in Rho GTPase signaling pathways. These knockout cell lines are genetically modified to completely disable the ARHGEF9 gene, thereby providing a platform for elucidating its contributions to cellular processes, including cytoskeletal organization, cell migration, and signal transduction.

The primary function of ARHGEF9 Gene Knockout Cell Lines is to facilitate the study of ARHGEF9's role within various biological systems by enabling comparative analyses with wild-type cell lines. Researchers can observe the phenotypic consequences of gene loss, including alterations in cell behavior and signaling cascades. The mechanistic insights gained from these studies are invaluable in understanding diseases where the dysregulation of Rho GTPases is implicated, such as cancer metastasis, neurodegenerative disorders, and developmental anomalies.

In both research and clinical settings, these cell lines serve as a critical resource for functional genomics studies, drug discovery, and therapeutic development, providing significant advantages in assessing the molecular basis of ARHGEF9-related pathways. Compared to traditional methods of gene manipulation, the use of knockout cell lines allows for robust and reproducible results, minimizing off-target effects and enhancing the specificity of genetic investigations.

Researchers and clinicians will find ARHGEF9 Gene Knockout Cell Lines particularly valuable due to their ability to streamline experimentation and accelerate the translation of findings into potential treatments. This product opens new avenues in scientific discovery, empowering users to address complex biological questions with greater clarity and precision.

Our company specializes in producing high-quality, reliable biological products that advance research and enhance experimental outcomes. By providing these advanced ARHGEF9 Gene Knockout Cell Lines, we aim to support the scientific community in unraveling fundamental biological processes and addressing pressing health challenges.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.