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ARAP3 Knockout Cell Lines

Gene: ARAP3

Official Full Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3provided by HGNC

Gene Summary: This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Sep 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08690 ARAP3 Knockout cell line (HeLa) Human ARAP3 1:3~1:6 Negative Online Inquiry
KO08691 ARAP3 Knockout cell line (HCT 116) Human ARAP3 1:2~1:4 Negative Online Inquiry
KO08692 ARAP3 Knockout cell line (HEK293) Human ARAP3 1:3~1:6 Negative Online Inquiry
KO08693 ARAP3 Knockout cell line (A549) Human ARAP3 1:3~1:4 Negative Online Inquiry

Background

ARAP3 Gene Knockout Cell Lines are a specialized cellular model engineered to facilitate the study of the ARAP3 gene, a pivotal component in cellular processes such as endocytosis, cytoskeletal dynamics, and cell signaling pathways. This product exemplifies the application of CRISPR-Cas9 gene editing technology to produce specific knockouts of the ARAP3 gene, allowing researchers to discern the functional implications of ARAP3 in various biological contexts, including cancer biology, developmental studies, and immune responses.

The ARAP3 gene plays a critical role in regulating actin cytoskeleton reorganization and intracellular trafficking, thus influencing cellular motility and communication. By employing these knockout cell lines, scientists can investigate the downstream effects of ARAP3 absence, providing insights into how aberrations in this gene could contribute to pathologies. Furthermore, these cell lines serve as an invaluable tool in validating potential drug targets and unraveling molecular mechanisms underlying disease states.

One key advantage of the ARAP3 Gene Knockout Cell Lines is their precise genetic modification, which allows for the establishment of a stable phenotype that mirrors relevant biological conditions. Unlike traditional methods that may yield inconsistent expression patterns, our knockout lines ensure reproducibility and reliability in experimental outcomes. Additionally, the ease of incorporation into existing workflows makes it accessible for both high-throughput screenings and detailed mechanistic studies.

The scientific importance of utilizing ARAP3 Gene Knockout Cell Lines cannot be overstated; they open new avenues for research and therapeutic development in cancer, neurodegeneration, and autoimmune disorders. Their specificity and robustness empower researchers and clinicians alike to deepen their understanding of complex biological systems and pursue targeted interventions.

Our company prides itself on being at the forefront of cellular research products, providing high-quality, customized biological tools that meet the evolving needs of scientists. With our expertise in gene editing and cell line development, we are committed to supporting groundbreaking research and fostering innovations in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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