Gene: ARAP2
Official Full Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2provided by HGNC
Gene Summary: The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30477 | ARAP2 Knockout cell line (HeLa) | Human | ARAP2 | 1:3~1:6 | Negative | Online Inquiry |
KO30478 | ARAP2 Knockout cell line (HCT 116) | Human | ARAP2 | 1:2~1:4 | Negative | Online Inquiry |
KO30479 | ARAP2 Knockout cell line (HEK293) | Human | ARAP2 | 1:3~1:6 | Negative | Online Inquiry |
ARAP2 Gene Knockout Cell Lines are specialized cellular models engineered to specifically disrupt the ARAP2 gene, which encodes a protein involved in various cellular processes, including cell signaling and cytoskeletal dynamics. These cell lines serve as invaluable tools for researchers seeking to understand the biological functions of ARAP2, investigate its role in diseases, and explore potential therapeutic targets. The knockout mechanism is achieved using CRISPR-Cas9 technology, which allows for precise genome editing, leading to a complete loss of ARAP2 expression.
The key functions of ARAP2 include its involvement in regulating actin dynamics and modulating signaling pathways related to cell motility and proliferation. By studying these knockout cell lines, researchers can elucidate the pathways that ARAP2 influences, gain insights into related pathological conditions, such as cancer metastasis and neurological disorders, and assess how the absence of this gene alters cellular behavior. This mechanistic understanding is crucial for advancing drug discovery and developing novel therapeutic interventions.
One of the standout advantages of ARAP2 Gene Knockout Cell Lines is their specificity and reliability compared to traditional methods that often involve non-targeted approaches or systemic gene editing. These cell lines provide a consistent, reproducible platform for experimentation, with the straightforward ability to assess gene function through loss-of-function analysis.
The potential applications in both research and clinical settings are extensive. Researchers can utilize these cell lines for high-throughput screening, mutation studies, and functional assays, while clinicians may find them useful for elucidating the molecular basis of diseases associated with ARAP2 dysfunction.
Our company's expertise in cutting-edge genome editing technology ensures that we deliver high-quality, validated products that meet the rigorous standards of the scientific community. By choosing ARAP2 Gene Knockout Cell Lines, researchers and clinicians can leverage a reliable resource that accelerates their work and contributes to the ongoing pursuit of biomedical advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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