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ARAF Knockout Cell Lines

Gene: ARAF

Official Full Name: A-Raf proto-oncogene, serine/threonine kinaseprovided by HGNC

Gene Summary: Enables protein serine/threonine kinase activity. Involved in negative regulation of apoptotic process; regulation of TOR signaling; and regulation of protein metabolic process. Predicted to be active in cytosol and mitochondrion. Biomarker of high grade glioma. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00347 ARAF Knockout cell line(HEK293) Human ARAF 1:3~1:6 Negative Online Inquiry
KO08198 ARAF Knockout cell line (HeLa) Human ARAF 1:3~1:6 Negative Online Inquiry
KO08199 ARAF Knockout cell line (HCT 116) Human ARAF 1:2~1:4 Negative Online Inquiry
KO08200 ARAF Knockout cell line (A549) Human ARAF 1:3~1:4 Negative Online Inquiry

Background

ARAF Gene Knockout Cell Lines are specialized cellular models engineered to lack the ARAF gene, a member of the RAS family that plays a crucial role in cell signaling pathways involved in cell proliferation and differentiation. By specifically targeting and disrupting the ARAF gene, these cell lines serve as vital tools for understanding the gene's function and its contributions to various biological processes, particularly in oncogenic signaling pathways.

These cell lines operate through CRISPR/Cas9 gene editing technology, which allows for precise modifications in the cellular genome. The knockout of the ARAF gene leads to alterations in downstream signaling cascades, providing researchers with a means to dissect the cellular mechanisms underpinning cancer development and progression. This experimental system offers a platform for investigating therapeutic targets, drug resistance mechanisms, and the implications of ARAF dysregulation in various diseases.

The scientific importance of ARAF Gene Knockout Cell Lines extends into both basic and translational research. They enable the exploration of ARAF's role in tumorigenesis and provide a functional understanding that may address the challenges in targeted cancer therapies. Moreover, their application in drug discovery and validation processes adds to their utility in clinical settings, allowing researchers to assess potential compounds that could inhibit ARAF activity or its associated pathways.

Compared to other genetic knockout models, ARAF Gene Knockout Cell Lines present a unique advantage in their specificity and the fidelity of the gene disruption. This minimizes the risk of off-target effects commonly seen in traditional knockout methods, ensuring researchers achieve more reliable and reproducible results.

For clinicians and researchers focused on cancer biology and therapeutic development, these cell lines represent a valuable resource that can enhance insights into ARAF's role in disease and support the creation of innovative treatment strategies.

At [Your Company Name], we are dedicated to providing high-quality, rigorously validated biological products that empower scientific discovery. Our expertise in gene editing technologies ensures that our ARAF Gene Knockout Cell Lines meet the highest standards for research excellence.

Please note that all services are for research use only. Not intended for any clinical use.

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