Gene: APBB3
Official Full Name: amyloid beta precursor protein binding family B member 3provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07352 | APBB3 Knockout cell line (HeLa) | Human | APBB3 | 1:3~1:6 | Negative | Online Inquiry |
KO07353 | APBB3 Knockout cell line (HCT 116) | Human | APBB3 | 1:2~1:4 | Negative | Online Inquiry |
KO07354 | APBB3 Knockout cell line (A549) | Human | APBB3 | 1:3~1:4 | Negative | Online Inquiry |
APBB3 Gene Knockout Cell Lines are specialized cellular models engineered through targeted gene editing techniques to disrupt the expression of the APBB3 gene, a crucial component in various biological pathways including synaptic function and neurodevelopment. These cell lines possess a unique genetic profile that allows researchers to investigate the role of APBB3 in cellular processes, disease mechanisms, and drug responses, making them invaluable tools in genomics and biomedical studies.
The key function of these knockout cell lines lies in their capability to provide insights into the biological consequences of APBB3 deletion. By analyzing these cells, scientists can observe alterations in signaling pathways, gene expression patterns, and cellular behaviors that are associated with conditions such as neurodegenerative diseases and certain cancers. The lack of APBB3 enables the assessment of both compensatory mechanisms and the specific contributions of this gene to phenotypic outcomes, facilitating a deeper understanding of its role in health and disease.
From a scientific standpoint, the APBB3 Gene Knockout Cell Lines are pivotal in both research and clinical environments. They allow for high-throughput screening of therapeutic compounds, elucidation of disease pathways, and validation of genetic findings in human biology. The ability to mimic gene-specific alterations also fosters the development of precision medicine approaches, tailoring treatments to the genetic profile of individual patients.
Compared to alternative cell lines, the unique advantage of APBB3 knockout models lies in their specificity and reliability. Researchers often face challenges in attributing phenotypic changes to particular genes due to compensatory mechanisms in wild-type models; however, the knockout approach ensures that results are directly linked to the absence of the target gene.
For researchers, clinicians, and pharmaceutical developers, these knockout cell lines represent a powerful asset for accelerating discoveries and innovations in medical science. Their use can lead to breakthroughs in identifying potential therapeutic targets and understanding disease progression, enhancing both academic and translational research efforts.
At our company, we pride ourselves on our expertise in developing high-quality genetic products and cell lines. Our commitment to scientific excellence ensures that you receive reliable, cutting-edge tools that support your research objectives and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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